Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development

BMC Developmental Biology
Carolin SchilleAlexandra Schambony

Abstract

Bone morphogenetic proteins regulate multiple processes in embryonic development, including early dorso-ventral patterning and neural crest development. BMPs activate heteromeric receptor complexes consisting of type I and type II receptor-serine/threonine kinases. BMP receptors Ia and Ib, also known as ALK3 and ALK6 respectively, are the most common type I receptors that likely mediate most BMP signaling events. Since early expression patterns and functions in Xenopus laevis development have not been described, we have addressed these questions in the present study. Here we have analyzed the temporal and spatial expression patterns of ALK3 and ALK6; we have also carried out loss-of-function studies to define the function of these receptors in early Xenopus development. We detected both redundant and non-redundant roles of ALK3 and ALK6 in dorso-ventral patterning. From late gastrula stages onwards, their expression patterns diverged, which correlated with a specific, non-redundant requirement of ALK6 in post-gastrula neural crest cells. ALK6 was essential for induction of neural crest cell fate and further development of the neural crest and its derivatives. ALK3 and ALK6 both contribute to the gene regulatory network that reg...Continue Reading

References

Jan 1, 1991·Methods in Cell Biology·R M Harland
Nov 12, 1965·Science·M R Urist
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·B L RosenzweigK Miyazono
Dec 30, 1994·Biochemical and Biophysical Research Communications·N YamajiJ M Wozney
Jun 1, 1994·Genes & Development·R A RuppH Weintraub
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·A SuzukiN Ueno
Sep 1, 1994·Molecular and Cellular Biology·B B KoenigR A Grant
Aug 1, 1995·Mechanisms of Development·J H ClementW Knöchel
Aug 1, 1996·Current Opinion in Genetics & Development·B L Hogan
Sep 18, 1998·Mechanisms of Development·K NakataK Mikoshiba
Sep 25, 1998·The Journal of Biological Chemistry·M Macías-SilvaJ L Wrana
Dec 16, 1998·Genes & Development·Y Furuta, B L Hogan
Jun 4, 1999·Mechanisms of Development·M NikaidoN Ueno
Apr 25, 2000·The EMBO Journal·J Massagué, D Wotton
Aug 6, 2000·Developmental Biology·Y ShiS Evans
Dec 6, 2002·Endocrine Reviews·Hua ChangMartin M Matzuk
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
May 1, 1994·Trends in Cell Biology·J MassaguéJ L Wrana
Jun 10, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A S Tucker, J M W Slack
Sep 16, 2004·Journal of Cellular Biochemistry·Alexandra SnyderMargaret H Baron
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Edward M De Robertis, Hiroki Kuroda
Feb 5, 2005·Developmental Cell·Anne-Hélène Monsoro-BurqRichard Harland
Mar 23, 2005·Proceedings of the National Academy of Sciences of the United States of America·Byeong S YoonKaren M Lyons
Apr 5, 2005·Mechanisms of Development·Youngshin LimJeffrey Golden

❮ Previous
Next ❯

Citations

May 4, 2018·Wiley Interdisciplinary Reviews. Developmental Biology·Crystal D Rogers, Shuyi Nie
Jun 11, 2017·Cold Spring Harbor Perspectives in Biology·Joseph ZinskiMary C Mullins
Mar 30, 2017·Neurogenesis·Carolin Schille, Alexandra Schambony
Nov 6, 2020·Nature Communications·Hyeyoon LeeChristof Niehrs
Apr 9, 2021·Proceedings of the National Academy of Sciences of the United States of America·Benjamin TajerMary C Mullins

❮ Previous
Next ❯

Datasets Mentioned

BETA
KR052160

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.