Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets.

The Journal of Experimental Medicine
Michael W TuscheTak W Mak

Abstract

B cell activation factor of the TNF family (BAFF) activates noncanonical nuclear factor kappaB (NF-kappaB) heterodimers that promote B cell survival. We show that although MALT1 is largely dispensable for canonical NF-kappaB signaling downstream of the B cell receptor, the absence of MALT1 results in impaired BAFF-induced phosphorylation of NF-kappaB2 (p100), p100 degradation, and RelB nuclear translocation in B220(+) B cells. This corresponds with impaired survival of MALT1(-/-) marginal zone (MZ) but not follicular B cells in response to BAFF stimulation in vitro. MALT1(-/-) MZ B cells also express higher amounts of TRAF3, a known negative regulator of BAFF receptor-mediated signaling, and TRAF3 was found to interact with MALT1. Furthermore, phenotypes associated with overexpression of BAFF, including increased MZ B cell numbers, elevated serum immunoglobulin titers, and spontaneous germinal center formation, were found to be dependent on B cell-intrinsic MALT1 expression. Our results demonstrate a novel role for MALT1 in biological outcomes induced by BAFF-mediated signal transduction.

References

May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·L LingD V Goeddel
Jun 8, 1999·The Journal of Experimental Medicine·P SchneiderJ Tschopp
Dec 10, 1999·The Journal of Experimental Medicine·F MackayJ L Browning
Mar 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·S D KhareH Hsu
Nov 21, 2000·The Journal of Experimental Medicine·M BattenF Mackay
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D S WeihF Weih
Sep 28, 2002·Nature Immunology·Estefania ClaudioUlrich Siebenlist
Oct 3, 2002·Nature Reviews. Immunology·Qiutang Li, Inder M Verma
Oct 25, 2003·Science·Astrid A Ruefli-BrasseVishva M Dixit
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshiteru SasakiMarc Schmidt-Supprian
Sep 17, 2004·Genes & Development·Matthew S Hayden, Sankar Ghosh
Dec 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Xiangao HuangSelina Chen-Kiang
Apr 15, 2005·Molecular Immunology·Lai Guan NgFabienne Mackay
May 12, 2005·Current Opinion in Immunology·Pascal Schneider
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda L GavinDavid Nemazee
Aug 26, 2006·Seminars in Immunology·Fabienne Mackay, Helen Leung
Oct 25, 2006·The Journal of Experimental Medicine·Alina PatkeAlexander Tarakhovsky

❮ Previous
Next ❯

Citations

Dec 2, 2010·Cell Research·Jens StaalRudi Beyaert
Dec 22, 2010·Cell Research·Shao-Cong Sun
Dec 29, 2010·Cell Research·Marzenna Blonska, Xin Lin
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Queenie Lai Kwan LamLiwei Lu
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Takanori SoMichael Croft
Aug 27, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Linda M McAllister-LucasPeter C Lucas
Feb 2, 2011·PLoS Pathogens·Sonja I GringhuisTeunis B H Geijtenbeek
Sep 20, 2015·Biochimie·Janna Hachmann, Guy S Salvesen
Jan 21, 2016·Trends in Molecular Medicine·Annelies DemeyerRudi Beyaert
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Polina StepenskyKlaus Warnatz
Oct 29, 2015·Cellular and Molecular Life Sciences : CMLS·Maike Jaworski, Margot Thome
Mar 23, 2011·Trends in Immunology·Andrea CeruttiMontserrat Cols
Jun 14, 2013·Journal of Molecular Signaling·Ping Xie
Oct 25, 2011·Immunological Reviews·Robert C RickertAna V Miletic
Oct 25, 2011·Immunological Reviews·Joanne M HildebrandGail A Bishop
Mar 23, 2012·Immunological Reviews·Shao-Cong Sun
Jan 26, 2011·Histopathology·Ming-Qing Du
Jun 4, 2013·The Journal of Allergy and Clinical Immunology·Haifa H JabaraRaif S Geha
Jul 14, 2011·Cell Cycle·Shaun RosebeckLinda M McAllister-Lucas
Dec 18, 2013·The Journal of Allergy and Clinical Immunology·Margaret L McKinnonStuart E Turvey
Aug 11, 2016·Inflammatory Bowel Diseases·Dylan K McDanielIrving C Allen
May 17, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jiyeon HyeonYoung-Hyeh Ko
May 29, 2014·Current Opinion in Hematology·Jose A Martinez-Climent
Nov 19, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ping XieGail A Bishop
Feb 19, 2015·Nature Communications·Vishal KhairnarKarl S Lang
Oct 23, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mei YuDemin Wang
Dec 30, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peishan LeeRobert C Rickert
Jul 18, 2019·Journal of Leukocyte Biology·Mahdis MonajemiLaura M Sly

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
immunoprecipitation
ELISAs
ELISA
flow cytometry
fluorescence microscopy
nuclear translocation
ubiquitination
transgenic
lavage

Software Mentioned

FlowJo
Openlab

Related Concepts

Related Feeds

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.