Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster

Development
C C MiltonKieran F Harvey

Abstract

The Salvador-Warts-Hippo (SWH) pathway contains multiple growth-inhibitory proteins that control organ size during development by limiting activity of the Yorkie oncoprotein. Increasing evidence indicates that these growth inhibitors act in a complex network upstream of Yorkie. This complexity is emphasised by the distinct phenotypes of tissue lacking different SWH pathway genes. For example, eye tissue lacking the core SWH pathway components salvador, warts or hippo is highly overgrown and resistant to developmental apoptosis, whereas tissue lacking fat or expanded is not. Here we explore the relative contribution of SWH pathway proteins to organ size control by determining their temporal activity profile throughout Drosophila melanogaster eye development. We show that eye tissue lacking fat, expanded or discs overgrown displays elevated Yorkie activity during the larval growth phase of development, but not in the pupal eye when apoptosis ensues. Fat and Expanded do possess Yorkie-repressive activity in the pupal eye, but loss of fat or expanded at this stage of development can be compensated for by Merlin. Fat appears to repress Yorkie independently of Dachs in the pupal eye, which would contrast with the mode of action of Fa...Continue Reading

References

May 22, 2002·Nature Cell Biology·Soon Ji YooBruce A Hay
Jul 19, 2002·Current Biology : CB·Amy S RawlsTanya Wolff
Nov 8, 2002·Development·Madhuri Kango-SinghGeorg Halder
Sep 23, 2003·Nature Cell Biology·Ryan S UdanGeorg Halder
Sep 23, 2003·Nature Cell Biology·Sophie PantalacciPierre Léopold
Sep 5, 2006·Current Biology : CB·Riitta NoloGeorg Halder
Sep 19, 2006·Nature Genetics·Eunjoo ChoKenneth D Irvine
Sep 26, 2006·Current Biology : CB·Maria WilleckeGeorg Halder
Oct 19, 2006·Current Biology : CB·F Christian Bennett, Kieran F Harvey
Dec 19, 2006·Current Biology : CB·Cedric PoleselloNicolas Tapon
Feb 24, 2007·Nature Reviews. Cancer·Kieran Harvey, Nicolas Tapon
Apr 18, 2007·Genes & Development·Duojia Pan
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yongqiang Feng, Kenneth D Irvine
Feb 27, 2008·The Journal of Cell Biology·Kieran F HarveyIswar K Hariharan
Aug 13, 2008·Developmental Cell·Dragana RoguljaKenneth D Irvine
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Maria WilleckeGeorg Halder
Jul 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yongqiang Feng, Kenneth D Irvine

❮ Previous
Next ❯

Citations

Aug 21, 2013·Nature Cell Biology·Joffrey L DegoutinKieran F Harvey
Dec 18, 2013·Nature Reviews. Drug Discovery·Randy Johnson, Georg Halder
Oct 10, 2013·Science Signaling·Leonie Enderle, Helen McNeill
Dec 9, 2010·Development·Georg Halder, Randy L Johnson
Nov 30, 2014·Developmental Biology·Yelda SerinagaogluXinwei Cao
Mar 10, 2016·Developmental Cell·Hyung-Lok ChungKwang-Wook Choi
Sep 16, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chloe Thomas, David Strutt
Dec 17, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Binnaz Kucuk Staley, Kenneth D Irvine
Nov 30, 2010·Developmental Biology·Felix A GruscheKieran F Harvey
Jul 31, 2012·Current Biology : CB·Carole L C PoonKieran F Harvey
Jul 14, 2010·Current Biology : CB·Felix A GruscheKieran F Harvey
Apr 7, 2010·Current Biology : CB·Brian S RobinsonKenneth H Moberg
Oct 19, 2010·Developmental Cell·Duojia Pan
Mar 4, 2018·The International Journal of Social Psychiatry·Tian LanXia Liu
Jun 8, 2021·PLoS Genetics·Jonathan M PojerKieran F Harvey
Aug 7, 2021·IScience·Jonathan M PojerKieran F Harvey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis