PMID: 7547463Jun 1, 1995Paper

Differential requirements for segment polarity genes in wingless signaling

Mechanisms of Development
J NoordermeerRoel Nusse

Abstract

The segment polarity genes wingless and engrailed are required throughout development of Drosophila. During early embryogenesis, these two genes are expressed in adjacent domains, in an inter-dependent way. Later, their expression is regulated by different mechanisms and becomes maintained by auto-regulation. To dissect the genetic requirements for the initial signaling between wingless and engrailed expressing cells, we have previously used a transgenic Drosophila strain that expresses wingless under the control of the heat shock promoter (HS-wg). Focusing on the later phases of wingless and engrailed regulation, we have now extended these studies, using embryos carrying various combinations of segment polarity mutations and the HS-wg transgene. We confirm some of the existing models of regulation of the expression of wingless and engrailed. In addition, we find that HS-wg embryos require engrailed for induction of ectopic endogenous wingless expression. Signaling from engrailed cells to this novel wingless expression domain is dependent on hedgehog but also on porcupine. We further demonstrate a novel requirement for hedgehog in maintenance of expression of engrailed itself.

References

Jan 24, 1992·Cell·P W Ingham, A Martinez Arias
Sep 12, 1991·Nature·P W InghamY Nakano
Aug 1, 1991·Mechanisms of Development·F GonzálezA Martinez Arias
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Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
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Sep 1, 1984·Wilhelm Roux's Archives of Developmental Biology·C Nüsslein-VolhardH Kluding

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Citations

Dec 5, 2006·Oncogene·A J Mikels, R Nusse
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·T Von OhlenJ E Hooper
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse

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