Differential requirements for T cells in viruslike particle- and rotavirus-induced protective immunity

Journal of Virology
Sarah E BluttMargaret E Conner

Abstract

Correlates of protection from rotavirus infection are controversial. We compared the roles of B and T lymphocytes in protective immunity induced either by intranasally administered nonreplicating viruslike particles or inactivated virus or by orally administered murine rotavirus. We found that protection induced by nonreplicating vaccines requires CD4(+) T cells and CD40/CD40L. In contrast, T cells were not required for short-term protective immunity induced by infection, but both T-cell-dependent and -independent mechanisms contributed to long-term maintenance of protection. Our findings indicate that more than one marker of protective immunity exists and that these markers depend on the vaccine that is administered.

References

Oct 29, 1997·Journal of Virology·C M O'NealM E Conner
Dec 24, 1997·Virology·M A Franco, H B Greenberg
Feb 9, 2000·Trends in Microbiology·M A Franco, H B Greenberg
Jul 11, 2001·Novartis Foundation Symposium·P A Offit
May 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Baoming JiangRoger I Glass
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah E BluttMargaret E Conner
May 10, 2003·Emerging Infectious Diseases·Umesh D ParasharRoger I Glass
Mar 23, 2004·Annual Review of Immunology·Sergio A QuezadaRandolph J Noelle

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Citations

May 14, 2010·Clinical and Vaccine Immunology : CVI·Stanley A Plotkin
Mar 10, 2011·Virology Journal·Karen KnippingBelinda Van't Land
Jul 23, 2009·Current Opinion in Infectious Diseases·Miguel L O'RyanGonzalo Osorio
Apr 8, 2009·Expert Review of Vaccines·Joel R Haynes
May 23, 2013·Journal of Leukocyte Biology·John E Butler, Marek Sinkora

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