PMID: 8445753Mar 1, 1993Paper

Differential response of arteries and vein grafts to blood flow reduction

Journal of Vascular Surgery
S W GaltJ J Gilbertson

Abstract

This study was undertaken to evaluate the effect of blood flow on the dimensions and cellular composition of normal arteries and freshly placed vein grafts (VG). Bilateral jugular vein interposition grafts were placed in the common carotid arteries of 12 New Zealand white rabbits, and blood flow was reduced on one side by external carotid artery ligation. Shear stress, tangential stress, vessel dimensions, and smooth muscle cell (SMC) proliferation of reduced-flow arteries and VG were compared with these measures in contralateral controls (CON). A sustained reduction in blood flow was documented at 4 weeks (13 +/- 4 ml/min reduced-flow vs 21 +/- 4 ml/min CON; p < 0.05). Reduced-flow carotid arteries had a smaller lumen radius and greater medial thickness compared with normal-flow arteries, but there was no difference in medial cross-sectional area or medial SMC volume and no differences in any intimal measurements. These changes resulted in normalization of shear stress (15.2 +/- 4.6 dynes/cm2 reduced-flow vs 13.6 +/- 2.5 dynes/cm2 CON; p = NS). All VG underwent a marked postimplantation hyperplasia in intima and media, but the major effect of flow reduction on VG dimensions occurred in the intima. Intimal thickness in reduced-...Continue Reading

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