PMID: 15374127Mar 1, 1997Paper

Differential response of articular cartilage from young growing and mature old mice to IL-1 and TGF-beta

Archives of Gerontology and Geriatrics
Erella LivneIsrael Blumenfeld

Abstract

Osteoarthritic lesions are observed in temporomandibular joint cartilage of ICR mice aged 7 months and older, accompanied by reduced proliferation and matrix synthesis. Transforming growth factor-beta (TGF-beta), is a multifactorial growth factor affecting matrix synthesis and cell proliferation in bone and cartilage, whereas interleukin-1 (IL-1) is involved in cartilage degradation. In order to establish the repair capacity of cartilage in aging, the response of cartilage from young and old animals to TGF-beta and IL-1 was studied. Mandibular condyles from young (1-month-old) and old (18-month-old) mice were cultured for up to 72 h in medium supplemented with TGF-beta1 or IL-1alpha. TGF-beta increased protein (+9.26%) and DNA (+36.0%) contents in young animals and DNA content (+19.49%) in old animals. Incorporations of [(3)H]thymidine and [(35)S]sulfate were enhanced in young (+254% and +116%, respectively) and in old (+22.6% and +6.88%, respectively) and animals and activity of alkaline phosphatase was induced in old animals. Treatment with IL-1 resulted in reduced DNA content in young (-35.76%) and old (-33.33%) animals, but acid phosphatase activity was induced in old animals. It is concluded that TGF-beta can induce anabol...Continue Reading

References

Aug 1, 1989·The Journal of Clinical Investigation·D D DeanJ F Woessner
Jan 1, 1989·Connective Tissue Research·R L SmithD J Schurman
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J MassaguéB Nadal-Ginard
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsM B Sporn
Sep 1, 1994·Osteoarthritis and Cartilage·E Livne

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Citations

Nov 10, 2005·Arthritis Research & Therapy·E N Blaney DavidsonW B van den Berg
Feb 17, 2010·Arthritis Research & Therapy·Peter M van der KraanWim B van den Berg
Jun 22, 2016·Cranio : the Journal of Craniomandibular Practice·Giovanna de Fátima Alves da CostaPatrícia Dos Santos Calderon
Feb 21, 2003·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Maria Angeles FuentesRobert J Hinton
Sep 1, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Cheng ManJing Hu
Mar 27, 2013·International Journal of Molecular Sciences·Juan LiQing Zhu
Oct 8, 2013·Human Reproduction Update·H M Brown, D L Russell
Oct 18, 2001·Clinical Orthopaedics and Related Research·S P ScullyW Qi
Feb 21, 2003·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Maria Angeles FuentesRobert J Hinton

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