Differential response of cull cow muscles to the hypertrophic actions of ractopamine-hydrogen chloride

Journal of Animal Science
J M GonzalezS E Johnson

Abstract

Ractopamine-HCl (RAC) is a beta-adrenergic agonist with variable effects on cattle performance and carcass variables. Cull cows fed RAC (200 mg . head(-1) . d(-1)) demonstrate an increased size of type I and II muscle fibers that does not translate into a larger ribeye area. The objective of this study was to examine the dose-dependent effects of RAC on cull cow muscle morphometrics. Eighty-eight cull beef cows representing 2 breed types (n = 44 each) were fed 0, 100, 200, and 300 mg . head(-1) . d(-1) of RAC for the last 28 d of a 54-d feeding period. On d 54, cows were slaughtered, and samples of the LM and semimembranosus muscle (SM) from 16 randomly selected carcasses (n = 4 per treatment) were taken for measurement of beta (2)-adrenergic receptors and type I, IIA, and IIX myosin heavy chain (MyHC) gene expression. Twenty-four hours postmortem, LM, SM, infraspinatus (INF), and vastus lateralis samples from 40 randomly selected carcasses (n = 10 per treatment) were obtained and frozen for immunohistochemical analysis. Muscle fiber cross-sectional area and diameter, MyHC isoform expression, and fiber-associated nuclei numbers were measured. Ractopamine dosage exhibited differential effects on muscle morphometrics and MyHC gen...Continue Reading

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Citations

Jul 12, 2008·Ecology Letters·Pieter T J JohnsonDaniel R Sutherland
Mar 7, 2013·Journal of Animal Science·M R LapinS E Johnson
Feb 23, 2021·Biochemistry and Biophysics Reports·Madelaine C BrearleyJohn M Brameld
May 7, 2020·Journal of Agricultural and Food Chemistry·Brigitte Picard, Mohammed Gagaoua

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