PMID: 2864671Aug 16, 1985Paper

Differential response of enzymes of glutamate metabolism in neuronal perikarya and synaptosomes in acute hyperammonemia in rat

Neuroscience Letters
G Y Subbalakshmi, C R Murthy


Activity levels of the enzymes of glutamate metabolism were determined in the neuronal perikarya and synaptosomes isolated from the cerebral cortex of normal and hyperammonemic rats. In neuronal perikarya, the activities of glutamate dehydrogenase, aspartate, alanine aminotransferases and glutamine synthetase were elevated in hyperammonemic states. In synaptosomes, glutamate dehydrogenase and aspartate aminotransferase were suppressed, while glutamine synthetase and glutaminase were elevated. These results suggested the involvement of neuronal perikarya in ammonia detoxification at least in acute hyperammonemic states.


Mar 25, 1977·Science·A Martinez-HernandezMichael D Norenberg
Jan 1, 1983·Progress in Neurobiology·E Kvamme
Jan 1, 1983·Neurochemistry International·G Y Subbalakshmi, C R Murthy
Jan 1, 1985·Neurochemistry International·J Jessy, C R Murthy


Mar 1, 1992·Metabolic Brain Disease·V L RaoR F Butterworth
Jul 1, 1992·Digestive Diseases and Sciences·G Girard, R F Butterworth
Jan 1, 1997·Brain Research Bulletin·A R JayakumarV Paul
Jan 16, 2010·The American Journal of Pathology·Kakulavarapu V Rama RaoMichael D Norenberg

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