PMID: 2508186Jan 1, 1989Paper

Differential response of human and rodent cell lines to chemical inhibition of the repair of potentially lethal damage

Radiation and Environmental Biophysics
J B LittleW K Dahlberg

Abstract

We have examined the effects of several classes of metabolic inhibitors on the repair of potentially lethal damage in density-inhibited cultures of two rodent and two human cell systems which differ in their growth characteristics. Aphidicolin, 1-beta-D-arabinofuranosylcytosine (ara-C) and hydroxyurea showed no effect on PLD repair, whereas the effects of 9-beta-D-arabinofuranosyladenine (ara-A) and 3-aminobenzamide (3-AB) were cell line dependent. For example, 3-AB suppressed PLD repair almost completely in CHO cells, but showed no inhibitory effects in human diploid fibroblasts. These results indicate that inhibitors of DNA replication and poly(ADP-ribose) synthesis are not efficient inhibitors of cellular recovery in irradiated cells and, moreover, that such effects may be cell line dependent.

References

May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·E P MalaiseS Grinfeld
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R R WeichselbaumJ B Little
Mar 1, 1980·The Biochemical Journal·M R Purnell, W J Whish
May 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E Ben-Hur, M M Elkind

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Citations

Sep 1, 1995·International Journal of Radiation Biology·P Virsik-PeuckertD Mehmel
Apr 23, 2010·Cancer Treatment Reviews·C PowellK J Harrington
Jan 4, 1998·Journal of Biomechanical Engineering·B R Donnelly, J Medige

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