Differential response of myofibrils and 10-nm filaments to a cocarcinogen

The American Journal of Anatomy
Y ToyamaH Holtzer

Abstract

Multinucleated myotubes containing large numbers of striated myofibrils and large numbers of longitudinally-oriented 10-nm filaments were treated with the cocarcinogen phorbol-12-myristate-13-acetate (PMA) for 24, 48 or 72 hours. The inhibitory effects of PMA on the accumulation of myofibrils was evident within 24 hours, and by 72 hours virtually all striated myofibrils had disappeared. In contrast, the density of the 10-nm filaments was greatly enhanced in these myofibril-depleted myotubes. These effects were not due to a generalized cytotoxicity, for PMA stimulated the replication of the presumptive myoblasts and fibroblasts present in these cultures. 24 hours after removing the PMA, these myotubes assembled a new set of striated myofibrils and the density of 10-nm filaments diminished proportionately.

References

Jan 1, 1978·Differentiation; Research in Biological Diversity·S A FelliniH Holtzer
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G RoveraL Diamond
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·H YamasakiP A Marks
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G S BennettH Holtzer
Apr 7, 1977·Nature·R CohenH Holtzer
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·H HoltzerA P Somlyo
Sep 1, 1968·The Journal of Cell Biology·H IshikawaH Holtzer

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Citations

Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J CroopH Holtzer
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·Y ToyamaH Holtzer
Jun 15, 2004·Experimental Cell Research·Mitsuru IshizukaTakashi Saito
Jan 1, 1982·Differentiation; Research in Biological Diversity·G CossuM Molinaro
Dec 1, 1982·Archives of Biochemistry and Biophysics·C M West, H Holtzer
Jan 1, 1984·Wilhelm Roux's Archives of Developmental Biology·Christopher M West

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