PMID: 9427065Jan 14, 1998Paper

Differential response of oxygen radical metabolism in rat heart, liver and kidney to cyclosporine A treatment

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
A HaberlandI Schimke

Abstract

The study was designed to elucidate whether cyclosporine A (Cy A) induces oxidative stress in heart, liver and kidney. Male Wistar rats were treated with NaCl (n = 7), cremophor (vehicle for Cy A: n = 7) and 30 mg/kg b.w. Cy A in cremophor (n = 7) daily for 4 weeks. Oxidized (GSSG) and reduced (GSH) glutathione, lipid peroxides and superoxide dismutase were measured in the organs. Increases in GSSG [nmol/mg prot.] and a compensatory rise in total GSH [nmol/mg prot.] indicating Cy A-induced oxidative stress were found in kidney (0.39 +/- 0.09 vs. 0.47 +/- 0.14 vs. 0.64 +/- 0.18; 20.71 +/- 3.86 vs. 21.07 +/- 3.86 vs. 28.14 +/- 3.37) and liver (0.51 +/- 0.11 vs. 0.51 +/- 0.09 vs. 0.65 +/- 0.25; 33.35 +/- 5.06 vs. 32.88 +/- 5.12 vs. 44.12 +/- 6.06) but not in heart. Cy A-induced oxidative stress may contribute to the hepatotoxicity and nephrotoxicity of this drug. After heart transplantation, accelerated allograft atherosclerosis limits transplantation success. We did not find any evidence that Cy A induces oxidative stress in the heart which might favour atherogenesis.

Citations

Dec 20, 2000·Transplantation Proceedings·C S Kwak, K C Mun
Jun 6, 2000·Advanced Drug Delivery Reviews·V S Trubetskoy
Mar 10, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P BárányA K Salahudeen
Oct 25, 2003·Renal Failure·Muragundla AnjaneyuluKanwaljit Chopra
Dec 28, 2006·Immunological Investigations·Ilker DurakAslihan Avci

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