PMID: 9437579Jan 23, 1998Paper

Differential responses in anterior pituitary luteinizing hormone (LH) content and LH beta- and alpha-subunit mRNA, and plasma concentrations of LH and testosterone, in bulls treated with the LH-releasing hormone agonist deslorelin

Domestic Animal Endocrinology
W J AspdenM J D'Occhio

Abstract

Anterior pituitary gland contents of LH and LH beta- and alpha-subunit mRNAs, and circulating concentrations of LH and testosterone, were determined in bulls treated with the LH-releasing hormone (LHRH) agonist deslorelin. Brahman (Bos indicus) bulls (14-month-old) were allocated to two groups and received the following: Control (n = 5), no treatment; Deslorelin (n = 4), four deslorelin implants (approximately 200 micrograms total deslorelin/day) for 36 d. Plasma concentrations of LH were higher in bulls treated with deslorelin on Day 1, had returned to typical levels by Day 8, and did not differ for control bulls and bulls treated with deslorelin from Day 8 to Day 29. Pituitary content of LH on Day 36 was reduced (P < 0.001) in bulls treated with deslorelin (33 +/- 4 ng/mg) compared with control bulls (553 +/- 142 ng/mg). Relative pituitary content of LH beta-subunit mRNA was also reduced on Day 36 in bulls treated with deslorelin (Control, 0.65 +/- 0.10; Deslorelin, 0.22 +/- 0.04; P = 0.003). However, alpha-subunit mRNA relative content did not differ (Control, 0.73 +/- 0.15; Deslorelin, 1.06 +/- 0.12; P > 0.05). Plasma concentrations of testosterone were increased over the period of the experiment in the bulls treated with d...Continue Reading

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Citations

Dec 14, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·James G W WenzelUday B Kompella
Jun 14, 2000·Animal Reproduction Science·M J D'OcchioT E Trigg
Nov 6, 2002·Animal Reproduction Science·Michael J D'OcchioTimothy E Trigg
Aug 17, 2005·Animal Reproduction Science·C A Herbert, T E Trigg
Jul 1, 2007·Zoo Biology·M L PattonL M Penfold
Jan 24, 2008·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Ilona KoperaBarbara Bilinska
Dec 14, 2007·Reproduction, Fertility, and Development·Jutta EymannDouglas C Eckery
Jun 29, 2005·Animal Reproduction Science·N RamakrishnappaP C K Leung

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