Differential responses of female and male brains to hypoxia in the marine medaka Oryzias melastigma

Aquatic Toxicology
Keng Po LaiRudolf Shiu-Sun Wu

Abstract

Hypoxia, an endocrine disruptor, affects synthesis and balance of sex steroid hormones, leading to reproductive impairment in both female and male fish. Cumulating reports demonstrated the alternation of hypothalamus-pituitary-gonad axis (HPG-axis) by hypoxia. However, the detail mechanism underlying how hypoxia may alter other brain functions remains largely unknown. In this report, we used marine medaka as a model and conducted a high-throughput RNA sequencing followed by bioinformatics analysis on hypoxia-exposed brain tissues, aiming to determine the change of transcriptional signature and to unravel the pathways that are induced by hypoxia. We found that hypoxia lead to dysregulation of brain functions (including synaptic transmission, axon guidance, potassium ion transport, neuron differentiation, and development of brain and pituitary gland), and also signaling pathways (e.g., gap junction, calcium signaling pathway, and GnRH signaling pathway). Our results further demonstrate gender-specific responses to hypoxia in female and male fish's brains, which provides novel insights into the mechanism underlying the hypoxia induced sex specific brain functions impairments.

References

Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z L WuD R Storm
May 1, 1996·Progress in Neurobiology·C NyakasP G Luiten
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·E T TzavaraJ Hanoune
May 3, 2001·Environmental Health Perspectives·A C Melo, J S Ramsdell
Jul 14, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·L G ParksL E Gray
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Juliane StieberAndreas Ludwig
Jul 26, 2005·Nature Genetics·Jernej UleRobert B Darnell
Jan 6, 2006·Environmental Health Perspectives·Jennifer A FentressAnn Oliver Cheek
Jun 13, 2006·Marine Environmental Research·Peter ThomasSusan Lawson
Dec 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lisa M HinesUNKNOWN World Health Organization/International Society for Biomedical Research on Alcoholism Study on State and Trait Markers of Al
May 26, 2009·Nucleic Acids Research·Ruben Nogales-CadenasAlberto Pascual-Montano
Apr 13, 2011·Biological Psychiatry·Sylvane DesrivièresBoris Tabakoff
Mar 16, 2012·Bioinformatics·Jing-Woei LiDavid Mittelman
May 11, 2012·Nucleic Acids Research·Daniel Tabas-MadridAlberto Pascual-Montano
Apr 25, 2013·Brain Research·Jonathan ChenLonny R Levin
Apr 17, 2014·Chemical Society Reviews·Tuhin PradhanJong Seung Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.