PMID: 8593999Nov 1, 1995Paper

Differential responses of global airway, terminal airway, and tissue impedances to histamine

Journal of Applied Physiology
Z HantosJ J Fredberg

Abstract

The forced oscillation and alveolar capsule techniques were applied to determine the input impedance of the lungs and the airway transfer impedances between 0.2 and 20 Hz in six open-chest dogs in the control state, during intravenous infusion of histamine at seven rates between 0.25 and 16 micrograms.kg-1.min-1, and after the infusion. In each condition, the input impedances seen from the alveolar capsules, i.e., terminal airway impedance (Zaw,ter), were measured by imposing 2- to 200-Hz oscillations from the capsules (B. L. K. Davey and J. H. T. Bates. Respir. Physiol. 91:165-182, 1993). Airway resistance (Raw) and inertance and tissue damping and elastance were derived from the lung impedance data. For all dogs, histamine progressively increased Raw and the real part of airway transfer impedance (airway transfer resistance), reaching, at 16 micrograms.kg-1.min-1, 241 +/- 109 (SD) and 370 +/- 186%, respectively, of the control value but caused greater, although locally highly variable, increases (769 +/- 716% of the control value) in the real part of Zaw,ter extrapolated to zero frequency (R0). With increasing doses of histamine, the changes in R0 always preceded those in Raw and airway transfer resistance implying that bronc...Continue Reading

Citations

Jun 19, 2002·Journal of Applied Physiology·Shinichiro TomiokaCharles G Irvin
Dec 10, 1999·Nature·P G HoltP D Sly
Apr 23, 2003·Anesthesia and Analgesia·Barna BabikZoltán Hantos
Oct 24, 1997·Journal of Applied Physiology·K R Lutchen, H Gillis
Jul 18, 2001·Journal of Applied Physiology·P V RomeroJ Lopez-Aguilar
Oct 23, 2002·Journal of Applied Physiology·Peter D SlyZoltan Hantos
Oct 12, 1999·Journal of Applied Physiology·F PetákP D Sly
Jan 31, 2002·Anesthesiology·Walid HabreFerenc Peták
Jun 24, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Aidan K CurranRichard W Chapman
Apr 9, 2005·Journal of Applied Physiology·Elizabeth M BozanichDebra J Turner
Oct 1, 1996·Journal of Applied Physiology·I A DreshajR J Martin
Jul 22, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shou-Jin DongChun Y Seow

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