PMID: 9423835Jan 10, 1998Paper

Differential responses of human mononuclear phagocytes to mycobacterial lipoarabinomannans: role of CD14 and the mannose receptor

Infection and Immunity
J BernardoM J Fenton

Abstract

CD14 is a signaling receptor for both gram-negative bacterial lipopolysaccharide (LPS) and mycobacterial lipoarabinomannan (LAM) that lacks terminal mannosyl units (AraLAM). In contrast, terminally mannosylated LAM (ManLAM) binds the macrophage mannose receptor (MMRc), although the ability of the MMRc to serve as a signaling receptor has not been previously reported. We compared the abilities of AraLAM and ManLAM to induce distinct responses in two monocytic cell populations, freshly isolated human peripheral blood monocytes (PBM) and monocyte-derived macrophages (MDM). The responses examined were chemotaxis and transient changes in free cytosolic calcium ([Ca2+]in). We found that AraLAM but not ManLAM was chemotactic for both PBM and MDM. Migration of these cells in vitro to AraLAM was specifically blocked by an anti-CD14 monoclonal antibody, suggesting that CD14 mediates the chemotactic response to AraLAM. Subsequently, we found that AraLAM induced a transient rise in [Ca2+]in levels within a subpopulation of PBM but not MDM. This response was blocked by anti-CD14 antibodies. In contrast, ManLAM induced a transient rise in [Ca2+]in levels within a subpopulation of MDM but not PBM. This response was blocked by either anti-CD14...Continue Reading

References

Dec 1, 1990·Journal of Clinical Microbiology·E SadaM Torres
Apr 1, 1990·American Journal of Respiratory Cell and Molecular Biology·P D Stahl
Sep 1, 1994·Immunity·J PuginR J Ulevitch
Oct 1, 1995·Journal of Leukocyte Biology·G R StrohmeierE R Simons
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·R L DeludeD T Golenbock
Mar 1, 1993·Immunology Today·H W Ziegler-Heitbrock, R J Ulevitch
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J D LeeR J Ulevitch
Jun 1, 1994·Current Biology : CB·M S Diamond, T A Springer
Nov 1, 1993·Journal of General Microbiology·S PrinzisP J Brennan
Jan 4, 1993·Journal of Immunological Methods·K E Van VlietJ A Van Strijp
Mar 1, 1996·Infection and Immunity·M J Fenton, M W Vermeulen
Dec 1, 1996·American Journal of Respiratory Cell and Molecular Biology·S ZimmerliJ D Ernst

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Citations

Feb 13, 2013·Clinical & Developmental Immunology·Magdalena DruszczynskaWieslawa Rudnicka
Jul 19, 2000·Infection and Immunity·C Astarie-DequekerI Maridonneau-Parini
Aug 18, 2000·Immunology and Cell Biology·E R Rhoades, H J Ullrich
Sep 28, 2004·American Journal of Respiratory and Critical Care Medicine·Catharina W WielandTom van der Poll
May 19, 2004·Allergy·S ClaeysC Bachert
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jordi B TorrellesLarry S Schlesinger
Apr 9, 2008·Immunology·Catharina W WielandTom van der Poll
Mar 30, 2013·Journal of the American Heart Association·Andra L BlomkalnsNeal L Weintraub
Jun 11, 1999·The Journal of Biological Chemistry·R SchwandnerC J Kirschning
Oct 6, 2005·The Journal of Experimental Medicine·Peter B KangLarry S Schlesinger
Apr 20, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S ClaeysC Bachert
Jan 7, 2004·Cellular Microbiology·Petros C KarakousisSusan E Dorman
Jan 28, 2006·AIDS Research and Human Retroviruses·Adrián G Rosas-TaracoMario C Salinas-Carmona
Feb 7, 2009·European Journal of Immunology·Panagiota XaplanteriFotini Paliogianni
Jun 18, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Murugesan V S RajaramLarry S Schlesinger
Feb 8, 2002·World Journal of Gastroenterology : WJG·Sheng-Wei LiChang-An Liu
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael K MansourStuart M Levitz
Mar 19, 2004·Immunology·M Salomé GomesRui Appelberg
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teresa Greenwell-WildSharon M Wahl
Mar 5, 2003·Cellular Microbiology·Jeffrey S Schorey, Andrea M Cooper
Apr 26, 2003·Journal of Leukocyte Biology·Luisa Martinez-PomaresSimon Y C Wong
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J NigouG Puzo
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcello ChieppaPaola Allavena
Jul 19, 2013·Seminars in Immunopathology·Evelyn GuiradoGilla Kaplan
Apr 2, 1998·Current Opinion in Immunology·P D Stahl, R A Ezekowitz
Dec 28, 1999·Microbes and Infection·G R Strohmeier, M J Fenton
Oct 29, 2000·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·J S Ferguson, L S Schlesinger
Nov 14, 2008·Burns : Journal of the International Society for Burn Injuries·Hiroyoshi KawaaiKenji Taki

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