Differential responses to growth factors by normal human mesothelial cultures from individual donors

Journal of Cellular Physiology
J F LechnerE A Matis

Abstract

A significant interindividual variation in the growth rates is found in normal cultured human mesothelial (NHM) cells derived from different donors. This variation is observed when the mesothelial cells are incubated in medium containing serum and when the potencies of several separate growth factors are measured by using defined media. Depending on the donor, gamma-interferon and interleukin-2 can be toxic, have no effect, or stimulate the growth rate of NHM cells. Cultured NHM cells can be induced to multiply by growth factors that are released by activated macrophages. Thus, interindividual variation in NHM cell growth control could play a role in the pathogenesis of mesothelioma for a person exposed to asbestos.

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Citations

Oct 1, 1992·The Journal of Experimental Medicine·N JonjićA Mantovani
Feb 1, 1993·American Journal of Respiratory Cell and Molecular Biology·A Van der MeerenB I Gerwin
Dec 24, 1997·Environmental Health Perspectives·J F LechnerB I Gerwin
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Aug 3, 2002·Respirology : Official Journal of the Asian Pacific Society of Respirology·Steven E Mutsaers
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Jan 1, 1993·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·W M Elliott, N Auersperg
Oct 12, 2001·Annals of the New York Academy of Sciences·K L Sharpe-Timms

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