Differential Resting-State Functional Connectivity of Striatal Subregions in Bipolar Depression and Hypomania

Brain Connectivity
Murat I AltinayAmit Anand

Abstract

Bipolar disorder (BP) is characterized by periods of depression (BPD) and (hypo)mania (BPM), but the underlying state-related brain circuit abnormalities are not fully understood. Striatal functional activation and connectivity abnormalities have been noted in BP, but consistent findings have not been reported. To further elucidate striatal abnormalities in different BP states, this study investigated differences in resting-state functional connectivity of six striatal subregions in BPD, BPM, and healthy control (HC) subjects. Ninety medication-free subjects (30 BPD, 30 BPM, and 30 HC), closely matched for age and gender, were scanned using 3T functional magnetic resonance imaging (fMRI) acquired at resting state. Correlations of low-frequency blood oxygen level dependent signal fluctuations for six previously described striatal subregions were used to obtain connectivity maps of each subregion. Using a factorial design, main effects for differences between groups were obtained and post hoc pairwise group comparisons performed. BPD showed increased connectivity of the dorsal caudal putamen with somatosensory areas such as the insula and temporal gyrus. BPM group showed unique increased connectivity between left dorsal caudate a...Continue Reading

References

Feb 1, 1977·The Journal of Comparative Neurology·P S Goldman, W J Nauta
Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Mar 11, 1985·Brain Research·F T RusschenJ L Price
Sep 30, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J M Kemp, T P Powell
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Oct 1, 1996·Brain Research. Brain Research Reviews·J R Augustine
Jul 14, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G H GloverD Ress
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Sep 2, 2004·Molecular Psychiatry·S M StrakowskiC M Adler
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christian F BeckmannStephen M Smith
Mar 1, 2006·Journal of Affective Disorders·Michael P CaligiuriJames B Lohr
May 10, 2007·Developmental Neuropsychology·Erin D BiglerJanet E Lainhart
Apr 11, 2008·Cerebral Cortex·A Di MartinoM P Milham
Jul 9, 2008·Current Opinion in Neurology·Michael Greicius
Dec 20, 2008·Nature Reviews. Neuroscience·A D Bud Craig
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joseph L Price, Wayne C Drevets
Jan 26, 2010·Journal of Neuroscience Methods·Erik B Beall
Dec 24, 2010·Bipolar Disorders·William R Marchand, Deborah Yurgelun-Todd
Aug 4, 2011·NeuroImage·Koene R A Van DijkRandy L Buckner
May 29, 2012·Bipolar Disorders·Jennifer Townsend, Lori L Altshuler
Jul 9, 2013·Journal of Affective Disorders·Cristian VargasEduard Vieta

❮ Previous
Next ❯

Citations

Oct 30, 2016·Expert Review of Molecular Diagnostics·Antonio L TeixeiraRodrigo Machado-Vieira
Dec 27, 2016·Clinical Pharmacology and Therapeutics·D E NicholsC D Nichols
Dec 14, 2017·The Australian and New Zealand Journal of Psychiatry·Luciano MinuzziBenicio N Frey
Jun 15, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Shokouh ArjmandMohammad Shabani
Jan 3, 2021·European Archives of Psychiatry and Clinical Neuroscience·Li ZhangKai Wang
Mar 2, 2021·World Journal of Clinical Cases·Yin-Nan ZhangRen-Hua Wu
Apr 17, 2021·Molecular Psychiatry·Paola Magioncalda, Matteo Martino
Jun 9, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gwladys ReyPatrik Vuilleumier

❮ Previous
Next ❯

Software Mentioned

SLice
3dClustsim
- Oriented MOtion COrrection ( SLOMOCO )
SPSS
AFNI
SLOMOCO
Statistical Parametric Mapping
PESTICA ( Physiologic Estimation by Temporal Independent Compo...
AFNI ( Analysis of Functional Neuroimages )

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.