Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats

BMC Pharmacology & Toxicology
Ibrahim M ShokryRui Tao

Abstract

MDMA causes serotonin (5-HT) syndrome immediately after administration and serotonergic injury in a few days or weeks. However, a serotonin syndrome is not always followed by serotonergic injury, indicating different mechanisms responsible for two adverse effects. The goal of present study was to determine causes for two adverse events and further test that dose and environment have a differential role in initiating and intensifying MDMA neurotoxicity. Initiation and intensification were examined by comparing neurotoxic effects of a high-dose (10 mg/kg × 3 at 2 h intervals) with a low-dose (2 mg/kg × 3) under controlled-environmental conditions. Initiation of a serotonin syndrome was estimated by measuring extracellular 5-HT, body-core temperature, electroencephalogram and MDMA concentrations in the cerebrospinal fluid, while intensification determined in rats examined under modified environment. Initiation and intensification of the serotonergic injury were assessed in rats by measuring tissue 5-HT content, SERT density and functional integrity of serotonergic retrograde transportation. Both low- and high-dose could cause increases in extracellular 5-HT to elicit a serotonin syndrome at the same intensity. Modification of envi...Continue Reading

References

Dec 19, 1975·Brain Research·B L Jacobs, H Klemfuss
Feb 1, 1991·Pharmacology, Biochemistry, and Behavior·C J GordonD B Miller
Apr 1, 1993·Journal of Neuroscience Methods·D W Smith, T A Day
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Andrea C Nicholas, Lewis S Seiden
Oct 29, 2003·Toxicology Letters·Koichi UemuraKen-ichi Yoshida
Jun 6, 2006·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Piotr Olejniczak
Aug 19, 2007·The Journal of Pharmacology and Experimental Therapeutics·Daniel E RusyniakJoseph A DiMicco
Jul 25, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Melanie MuellerGeorge A Ricaurte
Oct 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Himashi AnverMartin Vreugdenhil
Apr 22, 2011·British Journal of Pharmacology·Daniel José BarbosaFélix Carvalho
Apr 23, 2013·Journal of Internal Medicine·S Ares-SantosR Moratalla
Apr 30, 2013·Frontiers in Integrative Neuroscience·Pau CeladaFrancesc Artigas
Oct 22, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marta ConcheiroMarilyn A Huestis
Jan 24, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Agatha LenartowiczSandra K Loo
Mar 1, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rui TaoZhiyuan Ma
Mar 13, 2014·Neurocase·Carla RuisIneke van der Ham
Apr 17, 2015·Journal of Neurophysiology·Max-Philipp StennerRaymond J Dolan
Jul 25, 2015·Drug and Alcohol Dependence·Gaël Le RouxDavid Boels
May 22, 2016·Brain Structure & Function·Sherie MaAndrew L Gundlach
Nov 15, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Vincent LaprevoteRaymund Schwan

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Citations

Dec 18, 2020·Pharmacological Reviews·Antonio InserraGabriella Gobbi
Oct 17, 2021·Experimental Neurology·Giulia Costa, Krystyna Gołembiowska

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