PMID: 7627811Apr 1, 1995Paper

Differential role of interferon-gamma in the potentiating effect of muramyl peptides for enhanced responses to lipopolysaccharide in mice: effect of cyclosporin A

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
A P BeigneuxM Parant


Cyclosporin A (CsA) administration reduced mortality in mice sensitized to endotoxic toxicity by various agents, such as muramyl dipeptide (MDP) or a lipophilic derivative. CsA is an inhibitor of a variety of T cell responses, suggesting that muramyl peptides could influence LPS-induced effects via the release of lymphokine. The potentiation of TNF production by pretreatment with muramyl peptides was comparable in nude mice and in controls, indicating that it is a T-independent mechanism, and CsA produced a similar inhibition in both groups. Neutralizing antibody to IFN-gamma did not change the elevated TNF level obtained in the blood when LPS was given after a muramyl peptide. However, the same treatment with anti-IFN-gamma MAb prevented the death of mice challenged with LPS plus MDP or plus a lipophilic derivative displaying similar effects. In comparing three selected muramyl peptides, we also show that the priming effect could be dissociated from the toxic synergism with LPS.


Apr 1, 1991·The Journal of Experimental Medicine·H R AlexanderJ A Norton
Jun 1, 1990·The Journal of Experimental Medicine·H HeremansA Billiau
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J Van SnickR J Simpson
Dec 1, 1987·European Journal of Immunology·A BilliauC Dillen
Jun 1, 1988·The Journal of Experimental Medicine·A Waage, T Espevik
Feb 1, 1982·Infection and Immunity·L A ChedidP L Lefrancier
Feb 1, 1981·Transplantation·M IntronaA Mantovani
Feb 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T A AdeleyeR Aston
Apr 1, 1993·The Journal of Experimental Medicine·M HowardS Menon

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