Differential role of organic anion-transporting polypeptides in estrone-3-sulphate uptake by breast epithelial cells and breast cancer cells

The Journal of Pharmacology and Experimental Therapeutics
Nilasha BanerjeeReina Bendayan

Abstract

The purpose of this study was to investigate the differential expression and function of organic anion-transporting polypeptides (OATPs) in breast epithelial and breast cancer cells. Estrone-3-sulfate (E3S), a substrate for 7 of 11 OATPs, is a predominant source of tumor estrogen in postmenopausal, hormone-dependent patients with breast cancer. Overexpression of certain OATPs (e.g., OATP1A2) reported in breast tumor tissues compared with surrounding normal tissues could contribute toward two to three times higher tumoral E3S concentration. Little is known about expression and function of other OATP family members among breast epithelial and breast cancer cells. We therefore compared gene and protein expression of seven OATPs (OATP1A2, OATP1B1, OATP1B3, OATP1C1, OATP2B1, OATP3A1, and OATP4A1) in immortalized breast epithelial cells (MCF10A), hormone-dependent breast cancer cells (MCF7), and hormone-independent breast cancer cells (MDA/LCC6-435, MDA-MB-231, and MDA-MB-468) by quantitative polymerase chain reaction and immunoblotting, respectively. Expression of solute carrier superfamily encoding for OATPs (SLCO) 1A2, 1B1, 1B3, 2B1, and 3A1 is exclusive, similar, or significantly higher in cancer cells compared with MCF10A cells....Continue Reading

References

Sep 1, 1985·The Journal of Pathology·D J Ferguson, T J Anderson
Dec 1, 1984·The Journal of Clinical Endocrinology and Metabolism·C VerheugenG Chaudhuri
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N VeberA Starzec
Jan 1, 1996·British Journal of Cancer·F LeonessaR Clarke
Mar 17, 1997·International Journal of Cancer. Journal International Du Cancer·J R PasqualiniA Ruiz
Mar 25, 2000·The Journal of Steroid Biochemistry and Molecular Biology·G S ChetriteJ R Pasqualini
Aug 5, 2000·The Journal of Steroid Biochemistry and Molecular Biology·T UtsumiN Harada
Nov 1, 2002·American Journal of Physiology. Endocrinology and Metabolism·Bernhard UgelePeer Hantschmann
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Rommel G TironaRichard B Kim
Jan 1, 2003·Biochimica Et Biophysica Acta·B Hagenbuch, P J Meier
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·F PizzagalliM V St-Pierre
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Jürgen Geisler
Aug 26, 2004·The Journal of Pharmacology and Experimental Therapeutics·Takashi NozawaIkumi Tamai
Feb 18, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Punam SandhuRichard B Kim
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Gernot ZollnerMichael Trauner
Apr 30, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Jorge R Pasqualini, Gérard S Chetrite
May 3, 2005·Pflügers Archiv : European journal of physiology·Abdul R AsifYohannes Hagos
Aug 29, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mizuki NinomiyaToshiharu Horie
Nov 8, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Anne KendallMitch Dowsett
Dec 23, 2006·Clinical Pharmacology and Therapeutics·N F SmithA Sparreboom
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Akinobu HamadaWilliam D Figg
Jun 6, 2008·Molecular Cancer Therapeutics·Ganapati V HegdeShantaram S Joshi
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B Hagenbuch, C Gui
Nov 22, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Evita van de SteegAlfred H Schinkel
Dec 17, 2008·Cancer Research·Wooin LeeWael El-Rifai
Dec 17, 2009·Trends in Pharmacological Sciences·Olena KisReina Bendayan
Jul 10, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Tomoji MaedaIkumi Tamai
Oct 20, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hannah M Linden, David A Mankoff
Jan 27, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jonathan L WrightElahe A Mostaghel
Mar 25, 2011·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jörg KönigMartin F Fromm
May 25, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ming YangPhilip W Kantoff
Jun 23, 2011·Molecular and Cellular Endocrinology·Atul PurohitBarry V L Potter
Aug 23, 2011·Annual Review of Pharmacology and Toxicology·Amanda ObaidatBruno Hagenbuch

❮ Previous
Next ❯

Citations

Jan 25, 2013·Pharmacological Reviews·Patrick T Ronaldson, Thomas P Davis
May 30, 2013·PloS One·Nilasha BanerjeeChristine Allen
Feb 23, 2013·Journal of Drug Delivery·Veronika Buxhofer-AuschTheresia Thalhammer
Jun 21, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Hartmut GlaeserKathrin Mandery
Dec 17, 2015·Steroids·Christian Bjerregaard-OlesenEva C Bonefeld-Jørgensen
Aug 27, 2014·Biopharmaceutics & Drug Disposition·Takeo Nakanishi, Ikumi Tamai
Sep 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Agnieszka Anna Rawłuszko-WieczorekPaweł Piotr Jagodziński
Mar 5, 2015·The AAPS Journal·Nilay ThakkarWooin Lee
Jun 21, 2016·Advanced Drug Delivery Reviews·Fanfan ZhouMichael Murray
Jun 28, 2016·European Journal of Pharmacology·Shotaro SasakiKen Iseki
Mar 20, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Zhaojian XiangMei Hong
Feb 21, 2019·Molecular Pharmacology·Rachael R Schulte, Richard H Ho
Feb 24, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xuefeng ZhangHaitang Xie
Sep 27, 2019·Protein and Peptide Letters·Ruipu SunRen Lai
Oct 31, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Rebeka JójártErzsébet Mernyák

❮ Previous
Next ❯