Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Bing ZhuSamia J Khoury

Abstract

Programmed death-1 (PD-1) is a negative costimulatory molecule, and blocking the interaction of PD-1 with its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), enhances autoimmune disease in several animal models. We have studied the role of PD-1 ligands in disease susceptibility and chronic progression in experimental autoimmune encephalomyelitis (EAE). In BALB/c mice immunized with myelin oligodendrocyte glycoprotein (MOG) peptide 35-55, PD-L1 but not PD-L2 blockade significantly increased EAE incidence. In B10.S mice immunized with myelin proteolipid protein (PLP) peptide 139-151, both PD-L1 and PD-L2 blockade markedly enhanced EAE severity. In prediabetic NOD mice immunized with PLP48-70, PD-L2 blockade worsened EAE but did not induce diabetes, whereas PD-L1 blockade precipitated diabetes but did not worsen EAE, suggesting different regulatory roles of these two ligands in EAE and diabetes. B6 mice immunized with MOG35-55 developed chronic persistent EAE, and PD-L2 blockade in the chronic phase exacerbated EAE, whereas PD-L1 blockade did not. In contrast, SJL/J mice immunized with PLP139-151 developed chronic relapsing-remitting EAE, and only PD-L1 blockade during remission precipitated EAE relapse. The strain-specific effects of P...Continue Reading

References

Jan 1, 1995·Annual Review of Immunology·S L Reiner, R M Locksley
Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Apr 3, 2001·The Journal of Experimental Medicine·S Y TsengH Tsuchiya
Apr 27, 2001·Trends in Immunology·H Nishimura, T Honjo
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·T OkazakiT Honjo
Feb 22, 2002·European Journal of Immunology·LauraL CarterBeatriz M Carreno
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Arthur A HurwitzJames P Allison
Nov 5, 2002·Current Opinion in Immunology·Fabienne Mackay, Susan L Kalled
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohide YamazakiHideo Yagita
Dec 26, 2002·Annual Review of Immunology·Susanne J SzaboLaurie H Glimcher
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·P'ng Loke, James P Allison
Jun 7, 2003·Journal of Autoimmunity·Hervé Groux, Françoise Cottrez
Jul 9, 2003·The Journal of Experimental Medicine·Tahiro ShinFranck Housseau
Jul 9, 2003·The Journal of Experimental Medicine·Mohammed Javeed I AnsariMohamed H Sayegh
Jul 9, 2003·The Journal of Experimental Medicine·Alan D SalamaSamia J Khoury
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iris LeeWayne W Hancock
Jan 10, 2004·Immunologic Research·Sharon M Wahl, Wanjun Chen
Jan 10, 2004·Immunologic Research·Shi-Jun Zheng, Youhai H Chen
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koichiro MatsumotoYoichi Nakanishi
Mar 24, 2004·Seminars in Immunology·Ciriaco A Piccirillo, Ethan M Shevach
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bernhard GreveVijay K Kuchroo
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens M ChemnitzJames L Riley
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yvette E LatchmanArlene H Sharpe
Oct 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jayagopala ReddyVijay K Kuchroo
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sigrid E SandnerMohamed H Sayegh
Mar 23, 2005·Biochemical and Biophysical Research Communications·Miyuki TsudaYoichi Nakanishi
May 18, 2005·The Journal of Experimental Medicine·Tahiro ShinDrew M Pardoll
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshiro ItoNader Najafian
May 25, 2005·Annals of Neurology·Antje KronerHeinz Wiendl
Jun 4, 2005·Arthritis and Rheumatism·Martin JohanssonSolbritt Rantapää-Dahlqvist
Jul 20, 2005·The Journal of Experimental Medicine·Indira GuleriaMohamed H Sayegh

❮ Previous
Next ❯

Citations

Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
Oct 11, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HabichtX C Li
Sep 15, 2007·The Journal of Clinical Investigation·Israel GotsmanAndrew H Lichtman
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erika D ReynosoShannon J Turley
Jul 1, 2010·International Immunology·Marguerite GhiottoDaniel Olive
Aug 21, 2015·Annals of the New York Academy of Sciences·Rebecca A LeeXuemei Zhong
Apr 7, 2019·Nature Biomedical Engineering·Peng ZhaoMingnan Chen
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monique LafonHeinz Wiendl
Apr 7, 2007·Journal of Immunotherapy·Dallas B Flies, Lieping Chen
Mar 11, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alla L ZozulyaHeinz Wiendl
Dec 6, 2008·World Journal of Gastroenterology : WJG·Ji ChenGui-Qiang Wang
Sep 28, 2007·European Journal of Immunology·Liqing WangWayne W Hancock
Nov 2, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Man LiYue-Qiu Gao
Oct 16, 2009·European Journal of Immunology·Svetlana KarakhanovaAlexander H Enk
Oct 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daria TrabattoniMario Clerici
Dec 17, 2010·Inflammation·Narjes SoleimanifarMohammad Hossein Nicknam
Feb 10, 2012·Hybridoma·Patcharee RitprajakMiyuki Azuma
Aug 27, 2014·Frontiers in Cellular Neuroscience·Sheetal BodhankarHalina Offner
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yuxiang RuiShunsuke Chikuma
Feb 17, 2007·Nature Immunology·Arlene H SharpeGordon J Freeman
Nov 26, 2008·Circulation Research·Israel GotsmanAndrew H Lichtman
Mar 30, 2007·Blood·Monica V GoldbergCharles G Drake
Feb 1, 2011·Annals of the New York Academy of Sciences·Brian T Fife, Kristen E Pauken
Sep 22, 2012·Clinical & Developmental Immunology·Norihiko Watanabe, Hiroshi Nakajima
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ai-Yu GongXian-Ming Chen
May 23, 2012·Clinical & Developmental Immunology·Esdy N RozaliW Joost Lesterhuis
Jul 1, 2014·Transplantation·Naoka Murakami, Leonardo V Riella
May 27, 2008·Nature Reviews. Immunology·Weiping Zou, Lieping Chen
Jun 26, 2012·Immunological Reviews·Nicole JollerVijay K Kuchroo
Jul 28, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ji ChenGui-Qiang Wang
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia MenkeVicki R Kelley
Oct 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Li WangRandolph J Noelle
Feb 22, 2007·The American Journal of Gastroenterology·Norikazu MatakiSoichiro Miura
Oct 1, 2008·European Journal of Immunology·Bettina SchreinerStephen D Miller

❮ Previous
Next ❯

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