Differential role of the basolateral amygdala 5-HT3 and 5-HT4 serotonin receptors upon ACPA-induced anxiolytic-like behaviors and emotional memory deficit in mice

Behavioural Brain Research
Hamid-Reza CheginiMohammad-Reza Zarrindast

Abstract

The critical role of cannabinoidergic and serotonergic systems of the amygdala in modulation of anxiety-like behaviors and emotional memory has already been demonstrated. The present study aimed to investigate the possible role of the basolateral amygdala (BLA) 5-HT3 and 5-HT4 serotonergic systems upon ACPA (CB1 cannabinoid receptor agonist)-induced anxiolytic-like behaviors and emotional memory impairment using the elevated plus-maze (EPM) test-retest paradigm in male mice. bilateral guide-cannulae were implanted to allow intra-BLA microinjection of serotonergic agents. the intraperitoneal injection of ACPA could induce anxiolytic-like behaviors and reduce the emotional memory formation. Intra-BLA injection of M-Chlorophenylbiguanide (M-Chl, a 5-HT3 serotonin receptor agonist) neither altered the anxiety-like behaviors nor the emotional memory formation by itself, while the higher dose of Y-25130 (a 5-HT3 serotonin receptor antagonist) reduced the emotional memory formation and locomotor activity but not the anxiety-like behaviors. Furthermore, injection of a higher dose of RS67333 and RS23597 (as 5-HT4 serotonin receptor agonist and antagonist, respectively) did not alter the anxiety-like behaviors, while reduced the emotiona...Continue Reading

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Citations

Sep 3, 2014·Pharmacology, Biochemistry, and Behavior·Mohammad NasehiMohammad-Reza Zarrindast
Feb 9, 2016·Pharmacology, Biochemistry, and Behavior·Mitra KhakpoorMohammad-Reza Zarrindast
Jan 29, 2016·Brain Research·Mohammad NasehiMohammad-Reza Zarrindast
Dec 2, 2015·Behavioural Processes·Javier Leonardo RicoKaren Corredor
Feb 15, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mohammad NasehiMohammad-Reza Zarrindast
Dec 20, 2014·Neuroscience Letters·Mohammad NasehiMohammad-Reza Zarrindast
Jan 13, 2016·Journal of Psychopharmacology·Shahram ZarrabianMohammad-Reza Zarrindast
Jan 13, 2017·Turkish Journal of Medical Sciences·Hoda RanjbarSara Karimi
Jun 15, 2016·Journal of Psychopharmacology·Mohammad NasehiMohammad-Reza Zarrindast
Nov 11, 2020·Neuroscience and Biobehavioral Reviews·Salar VaseghiMohammad-Reza Zarrindast

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