PMID: 7541633Jun 1, 1995Paper

Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins

Neuron
R CurtisK F Lee

Abstract

The receptor mechanisms mediating the retrograde axonal transport of the neurotrophins have been investigated in adult rats. We show that transport of the TrkB ligands NT-4 and BDNF to peripheral neurons is dependent on the low affinity neurotrophin receptor (LNR). Pharmacological manipulation of LNR in vivo using either an anti-LNR antibody or a soluble recombinant LNR extracellular domain completely blocked retrograde transport of NT-4 and BDNF to sensory neurons, while having minimal effects on the transport of NGF in either sensory or sympathetic neurons. Furthermore, in mice with a null mutation of LNR, the transport of NT-4 and BDNF, but not NGF, was dramatically reduced. These observations demonstrate a selective role for LNR in retrograde transport of the various neurotrophins from distinct target regions in vivo.

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Citations

Aug 25, 1997·The Journal of Comparative Neurology·S SarramM R Byers
Dec 22, 1999·The Journal of Comparative Neurology·C R BuckT C Cope
Nov 19, 1997·Journal of Neuroscience Research·H Jiang, G Guroff
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Mar 8, 2000·Progress in Neurobiology·G L Barrett
Nov 19, 2003·Neuroscience Letters·Jean-Dominique DelcroixPaul Fernyhough

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