Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr mice.

Journal of Leukocyte Biology
M Ursula NormanMichael J Hickey

Abstract

MRL/fas(lpr) mice, which undergo a systemic autoimmune disease with similarities to systemic lupus erythematosus (SLE), display reduced pathology and prolonged survival if rendered deficient in ICAM-1. However, it remains unclear whether this is a result of the ability of ICAM-1 to promote the immune response or mediate leukocyte recruitment. Therefore, the aim of these studies was to compare the role of ICAM-1 in the elevated leukocyte-endothelial interactions, which affect MRL/fas(lpr) mice. Intravital microscopy was used to compare leukocyte rolling and adhesion in postcapillary venules in the dermal and cerebral (pial) microcirculations of wild-type (ICAM+/+) and ICAM-1-deficient (ICAM-1-/-) MRL/fas(lpr) mice. In the dermal microcirculation of 16-week MRL/fas(lpr) mice, leukocyte adhesion was increased relative to nondiseased MRL+/+ mice. However, this increase was abolished in ICAM-1-/- MRL/fas(lpr) mice. ICAM-1 deficiency was also associated with reduced dermal pathology. In contrast, in the pial microcirculation, the elevation in leukocyte adhesion observed in ICAM+/+ MRL/fas(lpr) mice also occurred in ICAM-1-/- MRL/fas(lpr) mice. VCAM-1 expression was detectable in both vascular beds, but higher levels were detected in ...Continue Reading

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Citations

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Nov 1, 2011·Autoimmunity Reviews·Jacob Orme, Chandra Mohan
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Feb 26, 2009·Autoimmunity Reviews·Mehran Ghoreishi, Jan P Dutz
Dec 21, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Connie H Y WongMichael J Hickey
Aug 5, 2015·Nature Reviews. Rheumatology·Guo-Min Deng, George C Tsokos
Aug 25, 2012·Journal of Neuroimmunology·Sebastian StielkeChristian Mawrin
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