Abstract
MRL/fas(lpr) mice, which undergo a systemic autoimmune disease with similarities to systemic lupus erythematosus (SLE), display reduced pathology and prolonged survival if rendered deficient in ICAM-1. However, it remains unclear whether this is a result of the ability of ICAM-1 to promote the immune response or mediate leukocyte recruitment. Therefore, the aim of these studies was to compare the role of ICAM-1 in the elevated leukocyte-endothelial interactions, which affect MRL/fas(lpr) mice. Intravital microscopy was used to compare leukocyte rolling and adhesion in postcapillary venules in the dermal and cerebral (pial) microcirculations of wild-type (ICAM+/+) and ICAM-1-deficient (ICAM-1-/-) MRL/fas(lpr) mice. In the dermal microcirculation of 16-week MRL/fas(lpr) mice, leukocyte adhesion was increased relative to nondiseased MRL+/+ mice. However, this increase was abolished in ICAM-1-/- MRL/fas(lpr) mice. ICAM-1 deficiency was also associated with reduced dermal pathology. In contrast, in the pial microcirculation, the elevation in leukocyte adhesion observed in ICAM+/+ MRL/fas(lpr) mice also occurred in ICAM-1-/- MRL/fas(lpr) mice. VCAM-1 expression was detectable in both vascular beds, but higher levels were detected in ...Continue Reading
References
Oct 1, 1992·Kidney International·R P Wuthrich
Jun 14, 1991·Cell·M S DiamondT A Springer
Mar 1, 1994·Arthritis and Rheumatism·H M BelmontS Abramson
Sep 1, 1995·European Journal of Immunology·D R KohT W Mak
Sep 1, 1993·Annals of the Rheumatic Diseases·M PallisR J Powell
Dec 1, 1993·The Journal of Clinical Investigation·T TakeuchiT Abe
Mar 1, 1995·International Journal of Microcirculation, Clinical and Experimental·H BaatzF Krombach
May 8, 1997·Biochemical and Biophysical Research Communications·M VandermeerenJ Geysen
Sep 1, 1997·The Journal of Clinical Investigation·C M LloydJ C Gutierrez-Ramos
Oct 23, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M J HickeyP Kubes
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·D A SteeberT F Tedder
Oct 28, 1998·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·M J EppihimerD N Granger
Dec 17, 1998·The Journal of Clinical Investigation·B EngelhardtG Hoch
Sep 30, 1999·Current Opinion in Rheumatology·R G Lahita
Jan 8, 2000·Journal of Neuroimmunology·M Laschinger, B Engelhardt
Jan 11, 2000·Circulation Research·J Carvalho-TavaresP Kubes
Oct 27, 2001·Acta Physiologica Scandinavica·M J HickeyP Kubes
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J HickeyWill G James
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Will G JamesMichael J Hickey
Sep 27, 2003·Journal of Neuroimmunology·Andleeb Zameer, Steven A Hoffman
Jul 28, 2004·The American Journal of Pathology·Christopher G KevilDaniel C Bullard
Jan 19, 2005·British Journal of Pharmacology·M Ursula NormanMichael J Hickey
Feb 12, 2005·Science·Jennifer Couzin
Aug 17, 2005·Tissue Antigens·M U Norman, M J Hickey
Apr 26, 2006·Clinical and Experimental Immunology·W G JamesM J Hickey
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia L GregoryMichael J Hickey
Nov 23, 2006·The Journal of Experimental Medicine·Mia PhillipsonPaul Kubes
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaodong HeDaniel C Bullard
Citations
Dec 6, 2011·Biological Trace Element Research·Guanghuan WangXiaohu Xu
Dec 9, 2010·The Journal of Biological Chemistry·Jingming LiSarah X Zhang
Aug 6, 2014·Journal of Autoimmunity·Ming ZhaoQianjin Lu
Aug 18, 2010·Clinical and Experimental Nephrology·Mohamed Ismail Abd-ElkareemMahmoud Rezk Abdelwahed Hussein
Jan 8, 2015·Journal of Exercise Nutrition & Biochemistry·Jong Kui JunYoung Ran Lee
Jan 10, 2016·Arthritis Research & Therapy·Myles J LewisDavid P D'Cruz
Nov 1, 2011·Autoimmunity Reviews·Jacob Orme, Chandra Mohan
Mar 9, 2010·Journal of Neuroimmunology·Alexander JacobJessy J Alexander
Jan 26, 2010·Journal of Pharmacological and Toxicological Methods·Ellen L Hughes, Felicity N E Gavins
Feb 26, 2009·Autoimmunity Reviews·Mehran Ghoreishi, Jan P Dutz
Dec 21, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Connie H Y WongMichael J Hickey
Dec 3, 2010·Glia·Roser GorinaAnna M Planas
Jun 11, 2015·Immunology·Supriya D MahajanJessy J Alexander
Aug 5, 2015·Nature Reviews. Rheumatology·Guo-Min Deng, George C Tsokos
Aug 25, 2012·Journal of Neuroimmunology·Sebastian StielkeChristian Mawrin
Mar 31, 2015·PloS One·Yufeng ZhaiXianzhong Meng
Nov 14, 2014·PloS One·Karina Alves ToledoMarcelo Dias-Baruffi
Sep 23, 2014·PloS One·Renata CurciarelloTakahiro Kudo
Apr 29, 2016·Journal of Neurochemistry·Berta Anuncibay-SotoArsenio Fernández-López
Jul 5, 2015·Experimental Biology and Medicine·Felipe L de OliveiraAndrea Doria
Apr 18, 2009·Molecular Aspects of Medicine·Tobias JungTilman Grune
Aug 10, 2010·Lupus·M Ghoreishi, J P Dutz
Feb 22, 2012·Lupus·Q ChengE F Morand
Jul 4, 2017·International Journal of Molecular Sciences·Bo Kyung LeeYi-Sook Jung
Jul 23, 2019·Rheumatology·Weijuan DengYa Liu
May 22, 2016·Molecular and Cellular Biochemistry·Laura TomaAnca V Sima
Mar 6, 2015·American Journal of Physiology. Renal Physiology·Tang-Dong LiaoOscar A Carretero
Jun 12, 2010·Acta Biochimica Et Biophysica Sinica·Xin LiDuanfang Liao
Jun 27, 2013·Experimental Dermatology·Tao ChenTing-Ting Wang