Differential roles of peripheral and spinal endothelin receptors in the micturition reflex in rats

The Journal of Urology
Teruyuki OgawaN Yoshimura

Abstract

We investigated the effects of endothelin (ET) receptor activation in the bladder and the spinal cord on the micturition reflex in urethane anesthetized rats. The effects of ET receptor activation on bladder activity were examined during continuous infusion cystometrograms. ET-1 was administered intrathecally or intravesically in normal rats or rats pretreated with capsaicin. The effects of intravenous injection of the selective ETA receptor antagonist ABT-627, or selective ETB receptor antagonist A-192621 (Abbott Laboratories, Abbott Park, Illinois) intrathecal injection of the opioid receptor antagonist naloxone hydrochloride on changes in bladder activity induced by intravesical or intrathecal ET-1 administration were investigated. Intravesical injection of ET-1 (0.1 to 10 microM) induced detrusor overactivity, as evidenced by a decrease in intercontraction intervals, in a dose dependent manner. ET-1 induced detrusor overactivity was suppressed by intravenous application of ABT-627 (0.1 mg/kg) as well as capsaicin pretreatment but not by A-192621. In contrast, intrathecal injection of ET-1 (0.5 to 50 fmol) increased intercontraction intervals dose dependently and ET-1 at a higher dose (50 fmol) induced urinary retention. The...Continue Reading

References

Jan 1, 1989·Journal of Cardiovascular Pharmacology·S H FerreiraG de Nucci
Oct 1, 1988·The Journal of Urology·W D Steers, W C De Groat
Apr 16, 1993·Neuroscience Letters·J KameiY Kasuya
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·W C de Groat, N Yoshimura

❮ Previous
Next ❯

Citations

Jan 16, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·Emilio SaccoPierfrancesco Bassi
Jun 1, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Masashi UkaiMasao Sasamata
Nov 24, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Naoki YoshimuraPradeep Tyagi
Jul 9, 2013·Neurourology and Urodynamics·Naoki YoshimuraSatoru Yoshikawa
Feb 9, 2006·British Journal of Pharmacology·William C de Groat
Mar 1, 2012·Lower Urinary Tract Symptoms·Osamu IshizukaOsamu Nishizawa
Dec 22, 2009·Neurourology and Urodynamics·William C de Groat, Naoki Yoshimura
Nov 13, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Tomoyuki UchiyamaSatoshi Kuwabara
Nov 19, 2005·Peptides·Bhagya L PuppalaAnil Gulati
Jan 7, 2014·Journal of Pharmacological Sciences·Ayaka OsanoShizuo Yamada
Aug 19, 2007·Neurourology and Urodynamics·Tetsuya ImamuraOsamu Nishizawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.