Differential roles of Yersinia outer protein P-mediated inhibition of nuclear factor-kappa B in the induction of cell death in dendritic cells and macrophages

Journal of Medical Microbiology
Irena AdkinsSabine Gröbner

Abstract

Yersinia outer protein P (YopP) induces cell death in macrophages and dendritic cells (DC). In DC this YopP-dependent cell death coincides with the inhibition of nuclear factor-kappa B (NF-kappaB) activation. However, as shown by measurement of propidium iodide uptake via disrupted cellular membranes, the preincubation of DC with several NF-kappaB inhibitors prior to infection with Yersinia did not restore the death-inducing capacity of a YopP-deficient Yersinia mutant. These results suggest that in contrast to macrophages, in DC the YopP-dependent inhibition of NF-kappaB activation is not causative for the induction of cell death. Instead, in DC, the inhibition of mitogen-activated protein kinases (MAPKs), in particular, p38 and c-Jun N-terminal kinase, prior to infection with a YopP-deficient Yersinia mutant substituted the death-inducing capacity of the Yersinia wild-type strain, indicating that the YopP-dependent inhibition of MAPKs mediates Yersinia-induced DC death. The differences between DC and macrophages in the mechanisms of cell death induction by YopP presented herein might be crucial for the function of these antigen-presenting cells.

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Citations

Dec 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Alborz MahdaviDavid A Tirrell
Sep 29, 2009·International Journal of Medical Microbiology : IJMM·Jerry M WellsJurgen M Karczewski
Nov 6, 2012·Cellular Logistics·Jean-Philippe Semblat, Christian Doerig
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May 10, 2017·Viruses·Zhijiang MiaoXueshan Xia
Mar 17, 2016·World Journal of Biological Chemistry·Khavong Pha, Lorena Navarro
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Jul 29, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HillM-C Cuturi

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