PMID: 11336176May 5, 2001Paper

Differential salt-sensitivity in the pathogenesis of renal damage in SHR and stroke prone SHR

American Journal of Hypertension
K A GriffinA K Bidani

Abstract

The spontaneously hypertensive rat (SHR) and the stroke prone SHR (SHRsp) display contrasting susceptibilities to the development of the severe hypertensive lesions of malignant nephrosclerosis, both with aging and after the provision of a high salt intake on the background of a Japanese style "stroke prone" rodent diet. The SHR is relatively resistant, whereas the SHRsp is markedly susceptible. The responsible mechanisms remain controversial. Blood pressure (BP) radiotelemetry was used to investigate the interrelationship between salt intake, systolic BP, and renal damage in 8- to 12-week-old male SHR and SHRsp given a standard North American style diet for 6 weeks, a standard diet plus 1% NaCl as drinking water for 6 weeks, or an 8% NaCl diet plus tap water for 4 weeks. After 4 weeks, BP was significantly greater in the SHRsp compared to the SHR and was significantly more sensitive to supplemental salt in the SHRsp than in SHR. Average systolic pressures during week 5 (after 4 weeks on standard diet plus tap water, standard diet plus 1% NaCl, and 8% NaCl diet plus tap water) were 188.0 +/- 3.0 mm Hg, 207.3 +/- 5.6 mm Hg, and 226 +/- 9.4 mm Hg in SHRsp compared with 171.4 +/- 3.8 mm Hg, 180.6 +/- 3.8 mm Hg, and 190.3 +/- 5.0 m...Continue Reading

Citations

Aug 15, 2020·Frontiers in Physiology·Samera NademiJeffrey G Dickhout
Mar 22, 2002·The New England Journal of Medicine·Richard J JohnsonBernardo Rodriguez-Iturbe
Sep 5, 2002·Physiological Genomics·Adamu AlemayehuMorton P Printz
Oct 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Haisong JuRobert N Willette
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Noriyoshi IshikawaToru Nabika
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Apr 11, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rodger LoutzenhiserAnil Bidani
Mar 2, 2010·Diabetes Care·Zachary T Bloomgarden
Jun 1, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Angela Schulz, Reinhold Kreutz
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Dec 4, 2019·Journal of the American Society of Nephrology : JASN·Anil K BidaniKaren A Griffin
Jun 5, 2002·Physiological Genomics·Chana YagilYoram Yagil
Dec 26, 2001·Current Opinion in Nephrology and Hypertension·Anil K Bidani, Karen A Griffin
Nov 18, 2003·Acta Physiologica Scandinavica·R D ManningN Tian
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Mar 11, 2004·Current Hypertension Reports·Karen A Griffin, Anil K Bidani
Jun 22, 2021·Clinical and Experimental Pharmacology & Physiology·Yusuke NagataniHideaki Higashino

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