Differential scanning calorimetry with curve-fitting program used to quantitatively analyze the polymorphic transformation of famotidine in the compressed compact

Drug Development and Industrial Pharmacy
Wen-Ting ChengShun-Li Wang

Abstract

Differential scanning calorimetry (DSC) combined with a curve-fitting program was utilized to quantitatively determine the polymorphic composition of famotidine in the compacts prepared by different compression treatments. Two types of famotidine compacts (compact I or II) were prepared by compressing a conical shape or a flattened shape of powder bed of famotidine form B. The compact I was constructed by a transparent region in the center with an opaque region surrounded outside, but the compact II was formed by a whole opaque region only. A drilled disc sample was prepared and then directly determined by DSC analysis. The Raman spectral results clearly indicate that all the compacts whether in any region before DSC determination were only of famotidine form B and independent of compression pressure applied. Under DSC determination, however, the curve-fitted relative compositions of form B in the drilled disc I sample were gradually reduced to 23-24% with the increase of compression pressure, whereas the curve-fitted relative composition of form A was slowly increased up to 76-77%. A transitional phase of famotidine form B (form B*) in the transparent region of the compact I after applying >150 kg/cm(2) of compression pressure...Continue Reading

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Citations

Jun 16, 2010·Drug Development and Industrial Pharmacy·A SantoveñaM Llabrés
Nov 7, 2009·Journal of Pharmaceutical Sciences·Harry G Brittain
Jan 18, 2011·Journal of Pharmaceutical and Biomedical Analysis·Norman ChiengJaakko Aaltonen
Jul 14, 2010·Journal of Pharmaceutical and Biomedical Analysis·Shan-Yang LinMing-Thau Sheu
Dec 23, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·René Holm, David P Elder

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