Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival

The Journal of Clinical Investigation
C G WillettMary E Sunday

Abstract

Transient pulmonary neuroendocrine cell hyperplasia and non-neuroendocrine lung tumors develop in nitrosaminetreated hamsters, which we hypothesized might modulate epithelial cell phenotype by expressing gene(s) homologous to human chromosome 3p gene(s) deleted in small cell carcinoma of the lung (SCLC). We differentially screened a chromosome 3 library using nitrosamine-treated versus normal hamster lung cDNAs and identified hepatocyte growth factor-like/macrophage-stimulating protein (HGFL/MSP) in injured lung. HGFL/MSP mRNA is low to undetectable in human SCLC and carcinoid tumors, but the HGFL/MSP tyrosine kinase receptor, RON, is present and functional on many of these neuroendocrine tumors. In H835, a pulmonary carcinoid cell line, and H187, a SCLC cell line, HGFL/ MSP induced adhesion/flattening and apoptosis. Using viable cell counts to assess proliferation after 14 d of treatment with HGFL/MSP, there is growth inhibition of H835 but not H187. Nitrosamine-treated hamsters also demonstrate pulmonary neuroendocrine cell apoptosis in situ during the same time period as expression of the endogenous HGFL/ MSP gene, immediately preceding the spontaneous regression of neuroendocrine cell hyperplasia. These observations suggest...Continue Reading

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Citations

Aug 14, 2003·Experimental Cell Research·Piera MaggioraMaria Flavia Di Renzo
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·Ling-Yi L ChangJames D Crapo
Jun 17, 2003·American Journal of Respiratory and Critical Care Medicine·Meera SubramaniamMary E Sunday
Dec 22, 2005·American Journal of Respiratory and Critical Care Medicine·Michael T Ganter, Jean-François Pittet
Apr 16, 1998·The Journal of Clinical Investigation·J A BezerraS J Degen
May 4, 1999·The Journal of Clinical Investigation·R S MuraokaS J Friezner Degen
Dec 17, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kristell BastideSylvie Chevillard
Nov 5, 2016·Journal of Cancer Research and Clinical Oncology·Omid ZareiSiavoush Dastmalchi
Jan 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jannik N AndersenNiels Peter H Møller
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May 26, 2006·Acta Pharmacologica Sinica·Ming-Hai WangYong-Qing Zhou
Jun 26, 2013·Nature Reviews. Cancer·Hang-Ping YaoMing-Hai Wang
Apr 25, 2001·Clinical and Laboratory Haematology·J E RimmerM Makris
Apr 6, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yanping KongMary E Sunday
Sep 10, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lin ShanMary E Sunday
Nov 24, 1999·The American Journal of Physiology·R L EmanuelM E Sunday
Aug 13, 1999·The American Journal of Physiology·B B BrimhallM E Sunday

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