Abstract
Interleukin-4 (IL-4) is a potent immunomodulatory cytokine synthesized and released by Th2 lymphocytes, mast cells and basophils. It has important effects on monocyte/macrophage cell lines, regulating the secretion of several cytokines, and the production of eicosanoids. In human monocytes and macrophages, IL-4 increases the expression of 15-lipoxygenase and 15-HETE production, but suppresses the inducible isoform of the prostaglandin H synthase (PGHS-2) enzyme and prostanoid synthesis. Prostanoids, in particular prostaglandin E2 (PGE2) have important functions in modulating inflammatory and fibrotic processes. We compared the effect of IL-4 on the expression of PGHS-2 in human alveolar macrophages (AM) and blood monocytes (BM) activated with physiologically distinct stimuli, lipopolysaccharide (LPS) or IL-1 in vitro. The induction of PGHS-2 mRNA and protein, and prostanoid synthesis by all stimuli was inhibited by exogenous IL-4 in both cell types. However, monocytes were more susceptible to this effect of IL-4 than alveolar macrophages.
References
Nov 1, 1992·Cellular Immunology·P ContiS Fiore
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M K O'BanionD A Young
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D J ConradE Sigal
Jan 1, 1989·The American Review of Respiratory Disease·R DworskiG A Fitzgerald
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P H HartJ A Hamilton
Mar 24, 1988·The New England Journal of Medicine·R B Johnston
Nov 23, 1995·Nature·J E DinchukP M Czerniak
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·M MurakamiJ P Arm
Oct 1, 1995·Journal of Cellular Physiology·T YanoG W Hunninghake
Oct 1, 1993·Research in Immunology·R de Waal MalefytJ E de Vries
Feb 1, 1994·Pulmonary Pharmacology·M Linden, R Brattsand
Mar 1, 1994·Journal of Leukocyte Biology·J A Hamilton
Jan 1, 1994·The Journal of Clinical Investigation·S L HempelG W Hunninghake
Aug 1, 1993·American Journal of Respiratory Cell and Molecular Biology·T J StandifordR M Strieter
Sep 1, 1993·The Journal of Clinical Investigation·B D LevyC N Serhan
Nov 3, 1995·Cell·R LangenbachO Smithies
Citations
Jun 6, 2002·Immunology·Javier Rangel MorenoRogelio Hernández Pando
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·B F McAdamG A FitzGerald
Jan 21, 2012·Journal of Allergy·John W SteinkeLarry Borish
Jun 27, 2013·PloS One·Daniel HeinrichsHacer Sahin
Nov 19, 2013·PLoS Pathogens·Darya A HaasThomas F Schulz
Oct 8, 2016·Immunology and Allergy Clinics of North America·John W SteinkeLarry Borish
Jan 1, 1998·Environmental Toxicology and Pharmacology·H J van HoofA Bast
Jan 16, 2015·American Journal of Rhinology & Allergy·John W Steinke, Larry Borish