PMID: 7547686Apr 1, 1995Paper

Differential sensitivity of human naive and memory CD4+ T cells for dexamethasone

International Immunology
E W NijhuisL Nagelkerken

Abstract

Human CD45RA+ ('naive') and CD45RO+ ('memory') CD4+ T cells were compared with respect to their sensitivity to dexamethasone (DEX). In three different activation pathways, i.e. (i) immobilized anti-CD3, (ii) immobilized anti-CD3 plus soluble anti-CD28 and (iii) soluble anti-CD2 plus soluble anti-CD28, naive CD4+ T cells appeared more sensitive to DEX than memory CD4+ T cells. In the anti-CD3 system this difference in sensitivity was apparent at a suboptimal DEX concentration. Addition of anti-CD28 rendered the cells largely insensitive to DEX, indicating that the CD28 pathway is less dependent of the DEX-sensitive transcription factor AP-1. However, the alternative pathway of T cell activation through CD2/CD28 triggering was highly sensitive to DEX when naive cells were studied; in the case of memory cells, at least a 10-fold higher DEX concentration was needed to achieve a comparable inhibition. The strong inhibitory effect of DEX on naive CD4+ T cells stimulated via the alternative pathway was completely abrogated by activation of protein kinase C (PKC) with phorbol myristate acetate. Our data suggest that at least two different mechanisms contribute to DEX resistance, i.e. CD28 triggering and PKC activation, which may occur ...Continue Reading

Citations

Aug 8, 2001·Immunology and Cell Biology·N Petrovsky
Jul 1, 2008·International Journal of Yoga·Sarika Arora, Jayashree Bhattacharjee
Jun 10, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Per MaritsSarah Thunberg
Aug 2, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kristin M ScheibleGloria S Pryhuber
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L Nagelkerken
Oct 27, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Krupa R MysoreXian C Li
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Moisés Evandro Bauer
Feb 29, 2020·Journal of Neuro-oncology·William J Kelly, Mark R Gilbert
Jul 19, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Carlo RiccardiGraziella Migliorati

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