Differential sensitivity of pinna reflex and esophageal temperature to clonidine in mice depleted of central noradrenaline by DSP-4

U Lerner, A Larsson


Mice injected with DSP-4 [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine], a selective noradrenergic neurotoxin, had marked depletions of central noradrenaline and an attenuated post-decapitation reflex. DSP-4-treated mice exhibited an increased sensitivity to the alpha 2-adrenoceptor agonist clonidine as measured by inhibition of the pinna reflex, but normal sensitivity as measured by hypothermia. This differential sensitivity may reflect the presence of supersensitive postsynaptic alpha 2-adrenoceptors in some, but not all, CNS regions after DSP-4 treatment.


Jun 1, 1980·The Journal of Pharmacy and Pharmacology·J Brown, S L Handley
Jul 1, 1982·The Journal of Pharmacy and Pharmacology·E Zacny
Feb 18, 1983·European Journal of Pharmacology·E MogilnickaA Delini-Stula

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