Differential sensitivity of rat exocrine and endocrine pancreas to cyclosporine

M K MüllerH Goebell


The effect of 5, 10, and 20 mg/kg bw cyclosporine on rat endocrine and exocrine pancreatic function was studied. Glucose-dependent insulin secretion from the endocrine pancreas was shown to be significantly impaired 8 days after cyclosporine was given once daily at a dose as low as 5 mg/kg. CCK-8-stimulated amylase and lipase secretion were less sensitive to the noxious effect of cyclosporine being impaired at a dose of 10 mg/kg. Trypsin secretion was shown to be impaired at 20 mg/kg cyclosporine only. Our results demonstrate that cyclosporine causes dose-dependent impairment of both pancreatic endocrine and exocrine functions: the endocrine pancreas being more sensitive to the noxious action than the exocrine pancreas.


May 1, 1990·Transplant International : Official Journal of the European Society for Organ Transplantation·W RiegelW H Hörl
May 1, 1993·Transplant International : Official Journal of the European Society for Organ Transplantation·L JanssonA Andersson
Nov 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J Mason
Aug 1, 1993·Digestive Diseases and Sciences·M K MüllerM V Singer
Sep 1, 1989·Klinische Wochenschrift·W H HörlH Wilms
Jan 1, 1992·Life Sciences·K TakaoriT Tobe
Apr 1, 1993·British Journal of Pharmacology·I H WaschulewskiJ M Edwardson
Jan 1, 1993·Digestive Diseases and Sciences·J V SchönfeldH Goebell
Apr 1, 1989·Transplant International : Official Journal of the European Society for Organ Transplantation·W RiegelW H Hörl
May 1, 1993·Metabolism: Clinical and Experimental·J von SchönfeldH Goebell

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