Differential sensitivity of Rauscher murine leukaemia virus (MuLV-R) to interferons in two interferon-responsive cell lines

The Journal of General Virology
P T AllenA Billiau

Abstract

The effect of interferon on the replication of vesicular stomatitis virus (VSV) and type-C oncornavirus in two Balb/c mouse cell lines, JLS-V5 and JLS-V9R, infected with MuLV-R was examined. VSV replication was inhibited threefold (0-5 log10) in both cell lines by 10 to 20 units of interferon/ml. In JLS-V5 cells C-type virus yields, as measured by 3H-uridine incorporation and reverse transcriptase activity, were also reduced threefold by 10 to 20 units of interferon/ml. However, in JLS-V9R cells, C-type virus replication was refractory to interferon at concentrations up to 1 x 10(4) units/ml. Infectious C-type virus transmitted from JLS-V9R cells to Balb/3TS cells was as sensitive to interferon as virus transmitted from JLS-V5 cells, indicating that resistance of C-type virus in JLS-V9R cells is a feature of the cells rather than of the virus strain.

Citations

Dec 1, 1993·Antiviral Research·C W Czarniecki
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H JacobsenR H Silverman
Jan 1, 1978·Archives of Virology·A BilliauP De Somer

Related Concepts

Antibiotic Resistance, Microbial
Interferons
Mice, Inbred BALB C
Rauscher Virus
Retroviridae
RNA-Directed DNA Polymerase
Vesicular stomatitis Indiana virus
Virus Replication

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