Differential sensitivity to tetrodotoxin and lack of effect of prostaglandin E2 on the pharmacology and physiology of propagated action potentials

British Journal of Pharmacology
K FarragR J Docherty

Abstract

1. We have studied the effects of prostaglandin E(2) (PGE(2)) on action potential propagation in the isolated, desheathed vagus and saphenous nerves of rats using an extracellular grease gap recording method. 2. PGE(2) evoked a small depolarization of vagus nerves but had no effect on the stimulation threshold, size or latency of either the A wave (corresponding to conduction in A fibres) or the C wave (corresponding to conduction in C fibres) of the compound action potential (CAP) recorded from either vagus or saphenous nerves. 3. Lidocaine (0.01 - 10 mM) reduced all components of the CAP of both vagus and saphenous nerves. PGE(2) had no significant effect on the sensitivity of any component of the CAP to lidocaine. 4. Tetrodotoxin (TTX, 10 microM) blocked completely both the A wave and the C wave of the CAP in either vagus or saphenous nerves. 5. In saphenous nerve preparations the A wave was blocked by lower concentrations of TTX than the C wave or any component of the CAP in vagus nerve preparations which suggests that somatosensory A fibres express a different sub-type of TTX-sensitive voltage-gated sodium channel (VGSC) than somatosensory C-fibres or visceral sensory fibres. 6. Chemical activation of VGSCs with veratridin...Continue Reading

References

Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·M S GoldJ D Levine
Jan 1, 1997·Journal of Neurophysiology·G D NicolA R Evans
Jul 1, 1998·British Journal of Pharmacology·J A SmithK R Bley
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S G WaxmanJ A Black
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·M S Gold
Jan 6, 2001·Neuron·A L GoldinW A Catterall

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Citations

May 3, 2005·Journal of Pharmacological and Toxicological Methods·R J DochertyS Costa
Dec 13, 2012·Nature Reviews. Neuroscience·Sulayman D Dib-HajjStephen G Waxman
Sep 14, 2007·Cephalalgia : an International Journal of Headache·J Ellrich, A Makowska
May 14, 2011·European Journal of Pain : EJP·Enilton A CamargoSoraia K P Costa
Jan 24, 2019·Physiological Reviews·David L BennettSulayman D Dib-Hajj
Sep 16, 2011·Journal of Neural Engineering·Jonathan J WaatajaChristopher N Honda
Oct 19, 2011·The Journal of Physiology·Yukiko MuroiBradley J Undem
May 15, 2003·British Journal of Pharmacology·Soraia K P CostaReginald J Docherty
Aug 7, 2021·Toxins·Ana Campos-RíosJosé Antonio Lamas
Oct 12, 2021·British Journal of Pharmacology·Marian KollarikBradley J Undem

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