PMID: 6708721Mar 19, 1984

Differential serotonin responses in the skeletal muscle microcirculation

Life Sciences
F R WilmothF N Miller

Abstract

Closed circuit television microscopy was used to quantitate in vivo responses of small vessels in the rat cremaster muscle to topically applied serotonin. Sprague-Dawley rats were anesthetized with a combination of urethane (800 mg/kg) and alpha-chloralose (60 mg/kg). The cremaster muscle with intact circulation and innervation was suspended in a bath which had controlled pH, pCO2, and pO2. Microvascular diameters of first order arterioles and venules and fourth-order arterioles were measured from the television monitor while serotonin (10(-9)M-10(-4)M) was added to the bath. Fourth-order arterioles (3-11 micron diameter) dilated to a maximum of 267% of their control value with a serotonin concentration of 10(-6)M. Serotonin (10(-4)M) constricted first-order arterioles (78-121 micron) to 61% of their control value. The threshold concentration (10(-8)M) for a serotonin-induced dilation of fourth-order arterioles was 1000 fold less than the threshold concentration (10(-5)M) for serotonin-induced constriction of first-order arterioles. Serotonin (10(-8)M - 10(-4)M) did not alter the diameter of first-order venules (115-195 micron) from the control value. The dose-dependent constriction of first-order arterioles and dose-dependent ...Continue Reading

References

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Citations

Jun 1, 1991·Journal of Neuroscience Research·E H JaffeB D Drujan
Jan 11, 2001·Physiology & Behavior·P F Frohlich, C M Meston
Sep 9, 2006·Medicine and Science in Sports and Exercise·Michele LabotzAndrew W Nichols
Aug 1, 1994·Journal of Cardiothoracic and Vascular Anesthesia·P J Van der Starre, R S Reneman
Jan 1, 1996·Medical & Biological Engineering & Computing·H CaiP A Oberg
Sep 25, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Stephanie W Watts
Jan 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·D A SchuschkeF N Miller
Jun 20, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Bridget M SeitzStephanie W Watts

Related Concepts

Metazoa
Structure of Arteriole
Dose-Response Relationship, Drug
Microcirculation
Muscle
August Rats
Hydroxytryptamine
Structure of Venule
Rats, Laboratory

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