PMID: 9526968Apr 4, 1998Paper

Differential short-term distribution of estrone and oleoyl-estrone administered in liposomes to lean and obese Zucker rats

Obesity Research
F BaladaM Alemany

Abstract

Thirteen-week-old female Zucker lean (Fa/Fa) and obese (fa/fa) rats were injected through a cannula inserted in the left jugular vein with 1 mL/kg of 3H-labeled oleoyl-estrone in liposomes (Merlin-2) (i.e., 670 fmol, 84 kBq). The rats were killed 10 minutes later and dissected. The presence of intact or hydrolyzed oleoyl-estrone was later determined in all samples. The pattern of distribution of estrone was quite different from that of oleoyl-estrone both in rats that were lean and in those that were obese. Estrone was better retained by white adipose tissue than oleoyl-estrone. Liver, spleen, and lungs accumulated more oleoyl-estrone and split part of it, from 4.7% (lung, obese) to 27% (liver, lean). The overall high retention of estrone by the rat tissues results in its very low circulating levels. The fast splitting of liposome-carried oleoyl-estrone by most tissues (up to more than 67% by intestine and skin of lean rats) may help explain the rise in blood free estrone. The differences between lean and obese Zucker rats are mainly quantitative in the case of estrone, the main differences being found in blood and adipose tissues. However, when we compare the data for oleoyl-estrone, the differences cannot be dismissed simply ...Continue Reading

References

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Citations

Mar 28, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·M M RomeroM Alemany
Nov 18, 1998·Journal of Microencapsulation
Feb 3, 2011·Medicinal Research Reviews·Xavier RemesarMarià Alemany
May 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M BlayM Alemany
Mar 27, 2010·Obesity·Sabine StrassburgDiego Perez-Tilve
Jan 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·X RemesarM Alemany

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