Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival

International Journal of Cancer. Journal International Du Cancer
Ian SpendloveTyson V Sharp

Abstract

The tumour suppressor gene (TSG) LIM domain containing protein 1 (LIMD1) has been associated with transformation of epithelial cells of the lung and its expression is downregulated in all lung tumour samples tested compared to normal lung matched controls. In the first study of its kind we used an anti-LIMD1 specific monoclonal antibody to investigate expression/localisation of the LIMD1 protein in a well-characterised tissue microarray of breast cancers and normal adjacent epithelia. Comparison of tumour with adjacent normal and distant normal tissue demonstrated that LIMD1 expression is moderate to high compared to tumour. There was also a significant correlation with histological grade (p = 0.0001), tumour size (p = 0.013) and tumour type (p = 0.004) indicating an association with aggressive disease. Cytoplasmic LIMD1 expression was seen in 99.3% of cases, with 43.1% showing both nuclear and cytoplasmic localisation. Absence/loss of nuclear staining showed a strong correlation with patient survival and was indicative of poor prognosis (p = 0.033). There was no association with lymph node status and other clinicopathological parameters. Nuclear staining was more pronounced in better prognosis tumours and normal tissue. This s...Continue Reading

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Citations

Mar 16, 2011·FEBS Letters·Daniel E FoxlerTyson V Sharp
Nov 8, 2011·Biology of the Cell·Semjon WillierThomas G P Grunewald
Feb 14, 2014·Cell Biology International·Adarsh K MayankSunil K Lal
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Guru Prasad MaitiChinmay Kumar Panda
Jun 23, 2018·EMBO Molecular Medicine·Daniel E FoxlerTyson V Sharp
Feb 15, 2018·Journal of Cell Science·Consuelo IbarKenneth D Irvine
Nov 13, 2021·Cell Death & Disease·Kathryn DavidsonTyson V Sharp

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