PMID: 3773523Oct 1, 1986Paper

Differential suppression of progesterone receptors by progesterone in the reproductive tract of female macaques

Journal of Steroid Biochemistry
N B WestR M Brenner

Abstract

Ovariectomized cynomolgus macaques were treated with implants of estradiol (E2) for 14 days. Some animals then received an additional implant of progesterone (P) for 7-14 more days. After treatment with either E2 alone or with E2 plus P we removed the reproductive tracts and measured nuclear and cytosolic P receptors by exchange assay. In addition we used steroid radioimmunoassays(RIA) to measure levels of E2 and P in parallel aliquots of the nuclear and cytosolic fractions. P treatment reduced the concentrations of E2 in nuclear and cytosolic fractions in the cervix, endometrium, myometrium and oviduct compared to the amounts present after 14 days of E2; these data are consistent with many reports that P treatment significantly lowers the amount of nuclear and cytosolic estrogen receptors in all of these tissues. In the oviduct, myometrium and cervix both cytosolic and nuclear P receptor levels were lowered during P action. In the endometrium, however, P treatment reduced the amount of P receptor only in the cytosolic but not the nuclear fraction. RIA determinations of the amount of P retained in nuclear fractions of the P-treated animals indicate that P levels were significantly elevated only in the nuclei obtained from endom...Continue Reading

References

Feb 1, 1975·Contraception·R GuerreroE Diczfalusy
Jan 1, 1975·Annual Review of Physiology·R M Brenner, N B West
Jun 1, 1975·The Journal of Clinical Endocrinology and Metabolism·D V IllingworthG Mikhail
Feb 1, 1977·Journal of Steroid Biochemistry·D V IllingworthG Mikhail
Apr 1, 1978·The Journal of Clinical Endocrinology and Metabolism·F BayardE E Baulieu
Sep 1, 1976·Journal of Steroid Biochemistry·B M SanbornH S Kuo
Aug 1, 1975·The Journal of Clinical Endocrinology and Metabolism·F BayardG Pontonnier
Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J A Resko
Jun 1, 1972·The Annals of Otology, Rhinology, and Laryngology·J VeredJ Sadé
Jul 1, 1983·Journal of Steroid Biochemistry·J PoortmanG P Alsbach
Mar 1, 1980·Clinical Obstetrics and Gynecology·W B Currie
Oct 1, 1980·The Journal of Clinical Endocrinology and Metabolism·H G VerhageR C Jaffe
Jun 1, 1981·The Journal of Clinical Endocrinology and Metabolism·F KuttennP Mauvais-Jarvis
Oct 1, 1981·Journal of Steroid Biochemistry·J C TsibrisW N Spellacy

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