Differential susceptibility of inbred mouse strains to Helicobacter pylori infection

Scandinavian Journal of Gastroenterology
M MählerH J Hedrich

Abstract

Host factors play an important part in the pathogenesis of Helicobacter pylori-associated disease. The aim of this study was to screen various inbred strains of mice for genetic differences in susceptibility to H. pylori infection. Mice of strains BALB/cJ, C.B-17-Prkdc(scid), C3H/HeJ, C3H/HeN, C57BL/6J, C57BL/6J-I110(tm/Cgn), DBA/2J, and FVB/N were inoculated intragastrically with H. pylori SS1. At 1, 4 and 6 months after inoculation, mice were necropsied, and bacterial cultures and histologic studies of the stomachs were performed. Significant differences in the level of colonization by H. pylori were observed among inbred strains at each time of infection. These differences were most distinct at 4 months after inoculation with highest levels in strains C3H/HeJ and C3H/HeN and lowest in strains FVB/N, C57BL/6J and C57BL/6J-I110(tm/Cgn). Infected mice revealed a mild increase in inflammatory cells compared with controls at 1 and 4 months, but not at 6 months after inoculation. The host strain effect on gastric disease was fairly mild, with two exceptions. Firstly, infected I110(tm/Cgn) mice developed a severe, hyperplastic gastritis, indicating that interleukin-10 is an important regulator of the inflammatory response to H. pyl...Continue Reading

Citations

Nov 23, 2006·Antimicrobial Agents and Chemotherapy·Sotirios ParaschosAlexios-Leandros Skaltsounis
Jan 9, 2004·Applied and Environmental Microbiology·D SgourasA Mentis
Oct 17, 2006·Clinical Microbiology Reviews·Holly M Scott Algood, Timothy L Cover
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Jun 27, 2014·The Journal of Oral Implantology·Flavia Q PirihPaulo M Camargo
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