PMID: 11926170Apr 3, 2002Paper

Differential susceptibility to ageing of rat preganglionic neurones projecting to the major pelvic ganglion and of their afferent inputs

Autonomic Neuroscience : Basic & Clinical
R M SanterA H D Watson

Abstract

We have analysed age-related changes in the morphology of preganglionic neurones in the lumbosacral spinal cord, labelled following injection of retrograde tracers into the major pelvic ganglion of young adult and aged male rats. We have also examined changes in neurotransmitter-characterised spinal afferent inputs to these neurones, or to the nuclei in which they lie, using light and electron microscope immunohistochemistry. In previous investigations of the major pelvic ganglion, the sympathetic, but not parasympathetic, postganglionic neurones were seen to exhibit age-related changes and the same pattern is seen in the preganglionic neurones. This included an apparent reduction in the numbers of sympathetic preganglionic neurones, and a reduction in the length of their dendrites and the complexity of their branches. Ultrastructural immunohistochemical studies described here reveal significant reductions in the area of synaptic contact made by glutamate-immunoreactive boutons onto the dendrites of sympathetic (but not parasympathetic) preganglionic neurones, while contacts from boutons immunoreactive for glycine or gamma-aminobutyric acid (GABA) were unchanged. There is also a reduction in synaptic contacts received by sympat...Continue Reading

References

Apr 23, 1990·Brain Research·A J Todd, V Lochhead
Jul 21, 1995·Neuroscience Letters·A L Warburton, R M Santer
Mar 1, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·N Yoshimura, W C de Groat
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Mar 10, 2000·Journal of Chemical Neuroanatomy·T HökfeltB Ulfhake

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Citations

Mar 30, 2004·Autonomic Neuroscience : Basic & Clinical·Diana OskutyteToshiki Murakami
Mar 21, 2007·Archives of Histology and Cytology·Huibing TanMasaru Kawabuchi
Feb 11, 2015·Biogerontology·Richard N Ranson, M Jill Saffrey
Jun 16, 2007·The Journal of Comparative Neurology·Ida J Llewellyn-SmithAnn M Schreihofer
Jan 22, 2005·Journal of Neurophysiology·Junichi KitagawaKoichi Iwata

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