PMID: 518245Dec 1, 1979Paper

Differential symptom reduction by drugs and psychotherapy in acute depression

Archives of General Psychiatry
A DiMascioG L Klerman

Abstract

A randomized, controlled trial compared the combination of amitriptyline hydrochloride and short-term interpersonal psychotherapy, either treatment alone, and a nonscheduled treatment control group in ambulatory acute, nonbipolar, nonpsychotic depressives. Results show the efficacy of both psychotherapy and amitriptyline in overall symptom reduction. Amitriptyline and psychotherapy were about equal, and the effects of both treatments in combination were additive. The additive effect of combined treatment was largely due to the differential effects of the two treatments. Amitriptyline had its effect mainly on the vegetative symptoms of depression such as sleep and appetite disturbance, these occurred early in treatment, often within the first week. Psychotherapy had its effect mainly on mood, suicidal ideation, work, and interests; these effects occurred slightly later, at four to eight weeks.

Citations

Apr 7, 2005·European Archives of Psychiatry and Clinical Neuroscience·Marcelo Feijo de MelloRichard Neugebauer
Jan 1, 1997·Journal of Affective Disorders·G ParkerM P Austin
Sep 12, 2008·Nature Reviews. Neuroscience·Robert J DeRubeisSteven D Hollon
Oct 23, 2010·BMC Psychiatry·Peeraphon Lueboonthavatchai, Nuntika Thavichachart
Feb 1, 1995·Controlled Clinical Trials·M S KamletM Wade
Nov 19, 2003·Journal of Consulting and Clinical Psychology·Shannon Wiltsey StirmanPamela E Brody
Feb 16, 2005·Journal of Consulting and Clinical Psychology·Shannon Wiltsey StirmanAllison Rothman
Sep 1, 1980·The Australian and New Zealand Journal of Psychiatry·R D Goldney, I Pilowsky
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·J TelnerG Mehta
Jan 15, 1992·Biological Psychiatry·D F KripkeJ C Gillin
Jan 1, 1989·European Archives of Psychiatry and Neurological Sciences·G L Klerman
Feb 1, 1994·Journal of Affective Disorders·G ParkerH Brodaty
Mar 1, 1988·Journal of Affective Disorders·E GillerM C Waldo
Jul 1, 1985·Journal of Affective Disorders·E S Paykel
Apr 1, 1984·Journal of Affective Disorders·M JacobP Bernstein
Sep 1, 1981·Journal of Affective Disorders·A J RushS D Hollon
Aug 11, 1995·Science·M M Weissman, M Olfson
Aug 24, 2006·Child Psychiatry and Human Development·Leena A KhanzodeHans Steiner
Jul 27, 2007·Issues in Mental Health Nursing·Tracy Stecker, Jennifer Alvidrez
Feb 1, 1981·Psychosomatics·R M Glass
Aug 1, 1982·Psychosomatics·I R Katz
Apr 1, 1995·American Journal of Community Psychology·R F MuñozL S Miller
May 19, 2010·Sleep Medicine·W Vaughn McCallPeter B Rosenquist
Jan 16, 2003·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Mark D MillerCharles F Reynolds
Oct 14, 2008·Journal of Affective Disorders·Dietrich van CalkerElisabeth Schramm
Jul 9, 2008·Contemporary Clinical Trials·William R LenderkingA John Rush
Feb 16, 2008·Journal of Affective Disorders·Sunil S BharAaron T Beck
Sep 6, 2006·Child and Adolescent Psychiatric Clinics of North America·Anat Brunstein Klomek, Laura Mufson
Dec 19, 2006·American Journal of Preventive Medicine·Ellen C Flannery-Schroeder
Feb 24, 2004·Depression and Anxiety·Helen VerdeliMyrna M Weissman
Sep 11, 2010·Depression and Anxiety·Steven D Hollon, Kathryn Ponniah
Apr 23, 2013·Acta Psychiatrica Scandinavica. Supplementum·L LampeL Berk
Sep 1, 1981·Comprehensive Psychiatry·H M Van Praag
Jan 1, 1984·Comprehensive Psychiatry·M M Weissman, H S Akiskal
Nov 1, 1983·Comprehensive Psychiatry·T R KostenH D Kleber
Mar 1, 1986·Journal of the American Geriatrics Society·I K WeissM K Aronson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.