Differential synchronization of leukemic cells in vivo by hydroxyurea

Leukemia Research
P C VincentR A Zbroja

Abstract

Flow cytometry (FCM) was used to monitor the cell cycle changes which occurred in the bone marrow cells of a patient with acute myeloblastic leukemia following pre-induction treatment with hydroxyurea. Flow cytometric and cytogenetic analysis showed two populations of cells; one hypertetraploid and presumably leukemic, and the other diploid and possibly normal. Sequential FCM monitoring of bone marrow cells after hydroxyurea demonstrated an early rise (after 24 h) in the S-phase component of diploid cells and a rise in the S-phase component of hypertetraploid cells 48-72 h later. Conventional induction therapy timed to coincide with this latter peak resulted in early remission.

References

Sep 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P D Noguchi, W C Browne
Oct 1, 1971·The Journal of Clinical Investigation·B C LampkinA M Mauer
Sep 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W Taylor

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Citations

Jan 1, 1985·Annals of the New York Academy of Sciences·P C Vincent
Feb 1, 1994·FEMS Immunology and Medical Microbiology·L M StevensonD G Jones
Dec 1, 1992·FEMS Microbiology Immunology·L M Stevenson, D G Jones
Jan 1, 1991·Microbiology and Immunology·H UshijimaW E Müller

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