Differential Systolic and Diastolic Regulation of the Cerebral Pressure-Flow Relationship During Squat-Stand Manoeuvres

Acta Neurochirurgica. Supplement
Jonathan D SmirlPaul van Donkelaar

Abstract

Cerebral pressure-flow dynamics are typically reported between mean arterial pressure and mean cerebral blood velocity. However, by reporting only mean responses, potential differential regulatory properties associated with systole and diastole may have been overlooked. Twenty young adults (16 male, age: 26.7 ± 6.6 years, BMI: 24.9 ± 3.0 kg/m2) were recruited for this study. Middle cerebral artery velocity was indexed via transcranial Doppler. Cerebral pressure-flow dynamics were assessed using transfer function analysis at both 0.05 and 0.10 Hz using squat-stand manoeuvres. This method provides robust and reliable measures for coherence (correlation index), phase (timing buffer) and gain (amplitude buffer) metrics. There were main effects for both cardiac cycle and frequency for phase and gain metrics (p < 0.001). The systolic phase (mean ± SD) was elevated at 0.05 (1.07 ± 0.51 radians) and 0.10 Hz (0.70 ± 0.46 radians) compared to the diastolic phase (0.05 Hz: 0.59 ± 0.14 radians; 0.10 Hz: 0.33 ± 0.11 radians). Conversely, the systolic normalized gain was reduced (0.05 Hz: 0.49 ± 0.12%/%; 0.10 Hz: 0.66 ± 0.20%/%) compared to the diastolic normalized gain (0.05 Hz: 1.46 ± 0.43%/%; 0.10 Hz: 1.97 ± 0.48%/%). These findings indic...Continue Reading

Citations

Jul 6, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ronney B PaneraiVictoria J Haunton
Nov 2, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Laura K Fitzgibbon-CollinsAndrew D Robertson
Jul 20, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David M SimpsonRonney B Panerai
Jul 30, 2021·Physiological Reports·Patrice BrassardPhilip N Ainslie
Nov 4, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joel S BurmaJonathan D Smirl

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