Differential targeting and signalling of voltage-gated T-type Cav 3.2 and L-type Cav 1.2 channels to ryanodine receptors in mesenteric arteries

The Journal of Physiology
Gang FanMaik Gollasch

Abstract

In arterial smooth muscle, Ca2+ sparks are elementary Ca2+ -release events generated by ryanodine receptors (RyRs) to cause vasodilatation by opening maxi Ca2+ -sensitive K+ (BKCa ) channels. This study elucidated the contribution of T-type Cav 3.2 channels in caveolae and their functional interaction with L-type Cav 1.2 channels to trigger Ca2+ sparks in vascular smooth muscle cells (VSMCs). Our data demonstrate that L-type Cav 1.2 channels provide the predominant Ca2+ pathway for the generation of Ca2+ sparks in murine arterial VSMCs. T-type Cav 3.2 channels represent an additional source for generation of VSMC Ca2+ sparks. They are located in pit structures of caveolae to provide locally restricted, tight coupling between T-type Cav 3.2 channels and RyRs to ignite Ca2+ sparks. Recent data suggest that T-type Cav 3.2 channels in arterial vascular smooth muscle cells (VSMCs) and pits structure of caveolae could contribute to elementary Ca2+ signalling (Ca2+ sparks) via ryanodine receptors (RyRs) to cause vasodilatation. While plausible, their precise involvement in igniting Ca2+ sparks remains largely unexplored. The goal of this study was to elucidate the contribution of caveolar Cav 3.2 channels and their functional interact...Continue Reading

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Citations

Mar 19, 2020·Aging Cell·Gang FanMaik Gollasch
Dec 5, 2019·Channels·Gang FanMario Kassmann
Jul 30, 2019·Frontiers in Medicine·Xiaoming LianMaik Gollasch
Jan 12, 2021·American Journal of Physiology. Endocrinology and Metabolism·Yefei Pang, Peter Thomas
Feb 23, 2021·Pulmonary Circulation·Guogu LiuAiguo Dai
Dec 29, 2020·Aging·Mario KassmannMaik Gollasch
Sep 13, 2020·Mechanisms of Ageing and Development·Osama F Harraz, Lars Jørn Jensen

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