Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders

Archives of General Psychiatry
Scott A SchobelScott A Small


Because schizophrenia and related disorders have a chronic time course and subtle histopathology, it is difficult to identify which brain regions are differentially targeted. To identify brain sites differentially targeted by schizophrenia, we applied a high-resolution variant of functional magnetic resonance imaging to clinically characterized patients and matched healthy controls and to a cohort of prodromal subjects who were prospectively followed up. Additionally, to explore the potential confound of medication use, the fMRI variant was applied to rodents receiving an antipsychotic agent. Cross-sectional and prospective cohort designs. Hospital clinic and magnetic resonance imaging laboratory. Eighteen patients with schizophrenia, 18 controls comparable in age and sex, and 18 prodromal patients followed up prospectively for 2 years. Ten C57-B mice received an antipsychotic agent or vehicle control. Regional cerebral blood volume (CBV), as measured with magnetic resonance imaging, and symptom severity, as measured with clinical rating scales. In a first between-group analysis that compared patients with schizophrenia with controls, results revealed abnormal CBV increases in the CA1 subfield and the orbitofrontal cortex and a...Continue Reading


Jul 14, 2010·Psychological Medicine·G K Murray
Jun 12, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Inna Gaisler-SalomonStephen Rayport
May 13, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kathryn M GillAnthony A Grace
Apr 25, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yijuan Du, Anthony A Grace
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michele P KellyNicholas J Brandon
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nicole M LewandowskiScott A Small
Apr 26, 2012·Schizophrenia Bulletin·C A TammingaSubroto Ghose
May 21, 2010·Journal of Psychiatric Practice·Norbert SkokauskasDavid A Kahn
Mar 17, 2012·Journal of Neurophysiology·Yuchun ZhangJohn E Lisman
Sep 12, 2012·Schizophrenia Research and Treatment·Cynthia G Wible
Jan 19, 2011·Imaging in Medicine·Judy L ThompsonAnissa Abi-Dargham
Aug 12, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jianhua Chu, Stewart A Anderson
Nov 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Robert M MitchellAndres Buonanno
Oct 8, 2013·Biological Psychiatry·Jason R Tregellas
Sep 8, 2011·Nature Reviews. Neuroscience·Scott A SmallCarol A Barnes
Dec 22, 2009·Expert Review of Neurotherapeutics·Elena Antonova, Veena Kumari
Jan 3, 2015·Trends in Neurosciences·Gemma ModinosPhilip K McGuire
Dec 3, 2014·Schizophrenia Research·Stephan Heckers, Christine Konradi
Feb 5, 2013·Journal of Proteomics·Narkhyun BaeGert Lubec
Nov 1, 2015·Human Brain Mapping·Jason SmucnyJason R Tregellas
Jun 28, 2011·Trends in Pharmacological Sciences·Daniel J Lodge, Anthony A Grace
Jun 4, 2011·Molecular and Cellular Neurosciences·Liam J DrewJoseph A Gogos
Mar 15, 2011·Biological Psychiatry·Ralph E HoffmanRisto Miikkulainen
Jun 19, 2010·Progress in Neurobiology·P R CorlettJ H Krystal
Sep 24, 2015·Molecular Psychiatry·M A Landek-SalgadoA Sawa
Feb 8, 2013·Brain : a Journal of Neurology·Kathrin C ZierhutKolja Schiltz
Oct 11, 2015·Schizophrenia Research·Jason R TregellasKaren E Stevens
Jan 21, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Guillermo HorgaBradley S Peterson


Jan 1, 1992·European Archives of Psychiatry and Clinical Neuroscience·Y KawasakiT Takashima
Apr 1, 1992·Brain : a Journal of Neurology·K J FristonR S Frackowiak
Feb 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J S PerlmutterM E Raichle
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Sep 1, 1974·Stroke; a Journal of Cerebral Circulation·R L GrubbM M Ter-Pogossian
Jan 1, 1996·Schizophrenia Bulletin·A R Yung, Patrick D McGorry
Jul 1, 1998·Biological Psychiatry·Francine M BenesM S Todtenkopf
Feb 25, 1999·Journal of Magnetic Resonance Imaging : JMRI·W LinR P Paczynski
Apr 9, 1999·Nature Neuroscience·Stephan HeckersN M Alpert
May 5, 1999·Schizophrenia Research·R T LoeberD A Yurgelun-Todd
Sep 3, 1999·Biological Psychiatry·Francine M Benes
Feb 15, 2001·Archives of General Psychiatry·J KlosterkötterF Schultze-Lutter
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J B MandevilleJ J Marota
May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M L WadenbergS Kapur
Dec 6, 2001·Hippocampus·D R MedoffC A Tamminga
Dec 18, 2001·The Journal of Comparative Neurology·X ZhaoFred H Gage
Nov 1, 2002·Schizophrenia Research·Lisa J PhillipsPatrick D McGorry
Feb 27, 2004·Schizophrenia Research·Alison YungPatrick D McGorry
Mar 3, 2004·Schizophrenia Bulletin·Stephen J WoodChristos Pantelis
May 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Scott A SmallCarol A Barnes
Oct 27, 2004·NeuroImage·Richard B BuxtonThomas T Liu
Dec 17, 2004·Biological Psychiatry·Dolores MalaspinaRonald Van Heertum
Apr 27, 2005·NeuroImage·Dominic E JobStephen M Lawrie
Mar 23, 2006·NMR in Biomedicine·Herman MorenoScott A Small
May 16, 2006·Journal of Psychiatric Research·Paolo BrambillaMichele Tansella
Nov 14, 2006·Biological Psychiatry·Stefan J BorgwardtPhilip K McGuire
Mar 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ana C PereiraScott A Small
Jun 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Francine M BenesMartin Minns

Related Concepts

Metabolic Process, Cellular
Neuro-Oncological Ventral Antigen 2
Imaging Studies
Antipsychotic Effect
Cerebral Blood Flow Imaging
Cortex Bone Disorders
Adrenal Cortex Diseases
Prefrontal Cortex
Magnetic Resonance Imaging
Positron-Emission Tomography

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