Differential temporal evolution of post-training changes in regional brain glucose metabolism induced by repeated spatial discrimination training in mice: visualization of the memory consolidation process?

The European Journal of Neuroscience
Bruno BontempiC Destrade

Abstract

The present study analyses the effects of the stage of learning on the spatial patterns and time-course of [14C]glucose uptake in BALB/c mice brain regions produced by spatial discrimination training in an eight-arm radial maze. Our particular approach was designed to follow, during the post-training period, the level of functional activity in individual brain areas which may underlie the memory consolidation process. Regional mapping of relative [14C]glucose uptake was assessed at three post-training time intervals (5 min, 1 and 3 h) after either the first (Day 1), the fourth (Day 4) or the last (Day 9) daily training session of the discrimination task and compared with sham-conditioned animals placed in the same experimental environment. The results indicated that numerous subcortical and cortical brain regions exhibit metabolic alterations following the acquisition of the spatial discrimination task. These alterations, which were specifically related to learning since they did not appear in sham-conditioned animals, were functions both of the post-training interval studied and of the degree of mastery of the task. On Day 1, a progressive, time-dependent and sequential increase in labelling was found from subcortical (5 min p...Continue Reading

References

Nov 1, 1979·Stroke; a Journal of Cerebral Circulation·R HawkinsJ Ransohoff
May 1, 1992·Science·J J Kim, M S Fanselow
Jan 1, 1991·Molecular Neurobiology·G SedmanK T Ng
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Jan 1, 1990·Teratogenesis, Carcinogenesis, and Mutagenesis·M D WatersT E Graedel
Mar 1, 1989·Behavioral and Neural Biology·I Izquierdo
Jan 1, 1989·Annual Review of Psychology·H Matthies
Sep 12, 1986·Science·E R JohnK Ono
Jan 1, 1985·The American Journal of Physiology·R A HawkinsL S Hibbard
Sep 16, 1966·Science·J L McGaugh
Jan 1, 1983·Annual Review of Psychology·J L McGaugh
Sep 1, 1984·Neuropathology and Applied Neurobiology·L Paljärvi, E V Snäll
Nov 1, 1983·The American Journal of Physiology·D M LuR A Hawkins
Apr 1, 1993·Brain Research. Molecular Brain Research·C HeurteauxM Lazdunski
Oct 1, 1957·Journal of Comparative and Physiological Psychology·L J KAMIN
Jun 1, 1963·Journal of Comparative and Physiological Psychology·F R BRUSHM E PALMER
Dec 1, 1962·Journal of Comparative and Physiological Psychology·M R DENNY, R E DITCHMAN
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT
Oct 30, 1987·Science·M Gallagher
Sep 1, 1949·The American Journal of Psychiatry·R W GERARD
Jul 1, 1992·Journal of Cognitive Neuroscience·H Eichenbaum
Apr 1, 1991·Journal of Cognitive Neuroscience·M R PolsterD L Schacter

❮ Previous
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Citations

Mar 29, 2002·Brain Research. Cognitive Brain Research·B Hauptmann, A Karni
Jun 4, 2004·Behavioral Neuroscience·Janine I RossatoIván Izquierdo
Nov 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marie E GibbsRoger J Summers
May 30, 2009·Behavioural Brain Research·Anita Cybulska-KlosowiczMalgorzata Kossut
Apr 1, 2008·Behavioural Brain Research·Jorge H MedinaIván Izquierdo
Jan 19, 2007·The European Journal of Neuroscience·A K Bruchey, F Gonzalez-Lima
Dec 14, 2004·Neuroscience·C ChoeiriC Messier
Dec 26, 2001·Neurobiology of Learning and Memory·Veronica V Galván, Norman M Weinberger
Nov 8, 2001·Consciousness and Cognition·J G Taylor
Oct 6, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·R JaffardC Destrade
Oct 4, 2006·Learning & Memory·Susan J Sara, Bernard Hars

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