Differential testosterone response to GnRH-induced LH release before and after musth in adult Asian elephant (Elephas maximus) bulls

Theriogenology
Chaleamchat SomgirdChatchote Thitaram

Abstract

Bull elephants exhibit marked increases in testosterone secretion during musth, and studies have shown a heightened sensitivity of the testis to GnRH-stimulated testosterone production in musth compared to nonmusth males. However, activity of the hypothalamo-pituitary-gonadal axis before or soon after musth has not been studied in detail. The aim of this study was to evaluate LH and testosterone responses to GnRH challenge in nine adult Asian elephant (Elephas maximus) bulls during three periods relative to musth: premusth, postmusth, and nonmusth. Bulls were administered 80 μg of a GnRH agonist, and blood was collected before and after injection to monitor serum hormone concentrations. The same bulls were injected with saline 2 weeks before each GnRH challenge and monitored using the same blood collection protocol. All bulls responded to GnRH, but not saline, with an increase in LH and testosterone during all three periods. The mean peak LH (1.76 ± 0.19 ng/mL; P < 0.001) and testosterone (6.71 ± 1.62 ng/mL; P = 0.019) concentrations after GnRH were higher than the respective baselines (0.57 ± 0.07 ng/mL, 3.05 ± 0.60 ng/mL). Although basal- and GnRH-induced LH secretion were similar across the stages, evaluation of the area und...Continue Reading

References

Feb 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K C Yeh, K C Kwan
Mar 1, 1994·The Journal of Clinical Endocrinology and Metabolism·C J BagatellW J Bremner
Jun 16, 2005·Physiological and Biochemical Zoology : PBZ·Andre GanswindtKeith Hodges
Mar 6, 2007·General and Comparative Endocrinology·Janine L BrownElizabeth W Freeman
May 1, 2007·General and Comparative Endocrinology·Lisa YonBill Lasley
Jun 3, 2009·Reproduction, Fertility, and Development·Chatchote ThitaramFrank J C M van Eerdenburg
Nov 3, 2010·The Journal of Veterinary Medical Science·Saroch KaewmaneeKazuyoshi Taya

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