Abstract
Dyslipidemia is commonly seen in patients with type 2 diabetes mellitus (T2DM). The current study sought to compare the effects of nateglinide and acarbose, two antihyperglycemic agents, on both fasting and postprandial lipid profiles in Chinese subjects with T2DM. For this multicenter, open-label, randomized, active-controlled, parallel-group study, 103 antihyperglycemic agent-naive patients with T2DM were recruited from four hospitals in China. In total, 85 subjects (44 in the nateglinide group, 41 in the acarbose group) with a known complete lipid profile underwent the entire clinical trial and were included in the final analysis. Serum was collected in the fasting state and 30 and 120 min after a standardized meal (postprandial states) to measure the baseline lipid profiles; the same testing was performed upon completion of a 2-week course of nateglinide (120 mg three times a day) or acarbose (50 mg three times a day). Fasting triglyceride (TG) levels were significantly reduced by both nateglinide and acarbose (P<0.001), with acarbose providing a significantly more robust improvement (vs. nateglinide, P=0.005). Additionally, the TG levels at both postprandial times were significantly reduced by acarbose (P<0.001 at 30 min a...Continue Reading
References
May 1, 1987·Metabolism: Clinical and Experimental·A D BaronO G Kolterman
Nov 1, 1985·American Heart Journal·W B Kannel
Jan 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·J L Chiasson
Nov 1, 1996·Diabetes Care·J L ChiassonT M Wolever
Jan 16, 1998·The American Journal of Medicine·J Hoffmann, M Spengler
Oct 13, 1998·Diabetes Research and Clinical Practice·S KadoN Nagata
Jun 16, 1999·Diabetes Research and Clinical Practice·R ScottT Welborn
May 26, 2001·The American Journal of Cardiology·W E Boden
Nov 7, 2002·Biological & Pharmaceutical Bulletin·Tomoyuki MineRyuzo Kawamori
Dec 7, 2002·Diabetes/metabolism Research and Reviews·Juha VakkilainenMarja-Riitta Taskinen
Mar 23, 2004·Endocrine·Yutaka MoriNaoko Tajima
Aug 4, 2004·Diabetes, Obesity & Metabolism·S OgawaS Ito
Aug 27, 2005·Diabetes Care·John GerichMichelle A Baron
Mar 23, 2007·Acta Pharmacologica Sinica·Hong-wei GaoTian-pei Hong
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Sandeep BansalPaul M Ridker
Sep 18, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Tomoya MitaRyuzo Kawamori
Jul 8, 2008·Journal of Atherosclerosis and Thrombosis·Tomokazu OyamaKohji Shirai
Feb 21, 2009·Nature Clinical Practice. Endocrinology & Metabolism·Arshag D Mooradian
Nov 15, 2011·Clinical Therapeutics·Jun-Sing WangWayne Huey-Herng Sheu
Jul 20, 2012·Current Medical Research and Opinion·Lu Ju-MingXue Yao-Ming
Mar 16, 2013·World Journal of Diabetes·Yuichi KojimaToru Hiyoshi
May 2, 2013·Diabetes Technology & Therapeutics·Jian ZhouWeiping Jia